School of Psychology and Counselling, Queensland University of Technology, Brisbane, Australia.
Faculty of Medicine, University of Queensland, Brisbane, Australia.
Sci Rep. 2024 Sep 6;14(1):20841. doi: 10.1038/s41598-024-71093-z.
Following on from our pilot studies, this study aimed to test the efficacy of a combination of probiotics (Lactobacillus acidophilus, Bifidobacterium bifidum, Streptococcus thermophilus), magnesium orotate and coenzyme 10 for the treatment of major depressive disorder (MDD) through a double-blind placebo controlled clinical trial. The participants were 120 adults diagnosed with MDD randomised to daily oral administration, over 8 weeks, of either the intervention or placebo, with a 16-week follow-up period. Intent-to-treat analysis found a significantly lower frequency of the presence of a major depressive episode in the intervention group compared with placebo at the end of the 8-week treatment phase, with no difference between the two conditions at 8-week follow-up. Both the categorical and continuous measure of depressive symptoms showed a significant difference between the two conditions at 4 weeks, but not 8 and 16 weeks. The secondary end-point was demonstrated with an overall reduction in self-rated symptoms of anxiety and stress in the active treatment group compared with placebo. These findings suggest that the combination of probiotics, magnesium orotate and coenzyme 10 may be an effective treatment of MDD over an 8-week period.
继我们的初步研究之后，本研究旨在通过双盲安慰剂对照临床试验，测试益生菌（嗜酸乳杆菌、双歧双歧杆菌、嗜热链球菌）、镁肌酸和辅酶 10 联合治疗重度抑郁症（MDD）的疗效。120 名被诊断为 MDD 的成年人被随机分为每日口服干预组或安慰剂组，共 8 周，16 周随访期。意向治疗分析发现，在 8 周治疗结束时，干预组出现重度抑郁发作的频率明显低于安慰剂组，而在 8 周随访时，两组之间没有差异。在 4 周时，分类和连续测量的抑郁症状在两种情况下均显示出显著差异，但在 8 周和 16 周时则没有。次要终点显示，与安慰剂相比，积极治疗组的自我报告焦虑和压力症状总体有所减轻。这些发现表明，益生菌、镁肌酸和辅酶 10 的联合治疗可能是 MDD 的有效治疗方法，治疗时间为 8 周。
