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用于生物医学图像联邦学习中系统偏差可解释识别的MyThisYourThat

MyThisYourThat for interpretable identification of systematic bias in federated learning for biomedical images.

作者信息

Naumova Klavdiia, Devos Arnout, Karimireddy Sai Praneeth, Jaggi Martin, Hartley Mary-Anne

机构信息

Laboratory for Intelligent Global Health and Humanitarian Response Technologies (LiGHT), Machine Learning and Optimization Laboratory, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.

ETH AI Center, Swiss Federal Institute of Technology Zurich (ETH Zurich), Zurich, Switzerland.

出版信息

NPJ Digit Med. 2024 Sep 7;7(1):238. doi: 10.1038/s41746-024-01226-1.

DOI:10.1038/s41746-024-01226-1
PMID:39242810
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11379706/
Abstract

Distributed collaborative learning is a promising approach for building predictive models for privacy-sensitive biomedical images. Here, several data owners (clients) train a joint model without sharing their original data. However, concealed systematic biases can compromise model performance and fairness. This study presents MyThisYourThat (MyTH) approach, which adapts an interpretable prototypical part learning network to a distributed setting, enabling each client to visualize feature differences learned by others on their own image: comparing one client's 'This' with others' 'That'. Our setting demonstrates four clients collaboratively training two diagnostic classifiers on a benchmark X-ray dataset. Without data bias, the global model reaches 74.14% balanced accuracy for cardiomegaly and 74.08% for pleural effusion. We show that with systematic visual bias in one client, the performance of global models drops to near-random. We demonstrate how differences between local and global prototypes reveal biases and allow their visualization on each client's data without compromising privacy.

摘要

分布式协作学习是一种很有前途的方法,用于为隐私敏感的生物医学图像构建预测模型。在这里,几个数据所有者(客户端)在不共享其原始数据的情况下训练一个联合模型。然而,隐藏的系统偏差可能会损害模型性能和公平性。本研究提出了MyThisYourThat(MyTH)方法,该方法将一个可解释的原型部分学习网络应用于分布式设置,使每个客户端能够在自己的图像上可视化其他客户端学到的特征差异:将一个客户端的“这个”与其他客户端的“那个”进行比较。我们的设置展示了四个客户端在一个基准X射线数据集上协作训练两个诊断分类器。在没有数据偏差的情况下,全局模型对心脏肥大的平衡准确率达到74.14%,对胸腔积液的平衡准确率达到74.08%。我们表明,在一个客户端存在系统视觉偏差的情况下,全局模型的性能会降至接近随机水平。我们展示了局部和全局原型之间的差异如何揭示偏差,并允许在不损害隐私的情况下在每个客户端的数据上进行可视化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d5/11379706/3a07872fff5c/41746_2024_1226_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d5/11379706/ceaa88e90e65/41746_2024_1226_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d5/11379706/7003e72fe770/41746_2024_1226_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d5/11379706/479d7446f03d/41746_2024_1226_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d5/11379706/60c3104e8d99/41746_2024_1226_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d5/11379706/3a07872fff5c/41746_2024_1226_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d5/11379706/ceaa88e90e65/41746_2024_1226_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d5/11379706/01afda47d1e3/41746_2024_1226_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d5/11379706/4e6fc0cd254f/41746_2024_1226_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d5/11379706/7003e72fe770/41746_2024_1226_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d5/11379706/479d7446f03d/41746_2024_1226_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d5/11379706/60c3104e8d99/41746_2024_1226_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1d5/11379706/3a07872fff5c/41746_2024_1226_Fig7_HTML.jpg

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本文引用的文献

1
Federated Learning for Medical Image Analysis with Deep Neural Networks.用于医学图像分析的深度神经网络联邦学习
Diagnostics (Basel). 2023 Apr 24;13(9):1532. doi: 10.3390/diagnostics13091532.
2
Effectiveness of Federated Learning and CNN Ensemble Architectures for Identifying Brain Tumors Using MRI Images.联邦学习和卷积神经网络集成架构在利用磁共振成像(MRI)图像识别脑肿瘤方面的有效性。
Neural Process Lett. 2022 Aug 28:1-31. doi: 10.1007/s11063-022-11014-1.
3
Explainable Deep Learning Models in Medical Image Analysis.医学图像分析中的可解释深度学习模型
J Imaging. 2020 Jun 20;6(6):52. doi: 10.3390/jimaging6060052.
4
The future of digital health with federated learning.联合学习助力数字健康的未来。
NPJ Digit Med. 2020 Sep 14;3:119. doi: 10.1038/s41746-020-00323-1. eCollection 2020.
5
Deep representation learning of electronic health records to unlock patient stratification at scale.电子健康记录的深度表征学习,以大规模实现患者分层。
NPJ Digit Med. 2020 Jul 17;3:96. doi: 10.1038/s41746-020-0301-z. eCollection 2020.
6
Deep Learning in Medical Image Analysis.医学图像分析中的深度学习
Annu Rev Biomed Eng. 2017 Jun 21;19:221-248. doi: 10.1146/annurev-bioeng-071516-044442. Epub 2017 Mar 9.