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癫痫患者何时需要治疗？药物的起始与停用。

When do epileptic patients need treatment? Starting and stopping medication.

作者信息

Chadwick D, Reynolds E H

出版信息

Br Med J (Clin Res Ed). 1985 Jun 22;290(6485):1885-8. doi: 10.1136/bmj.290.6485.1885.

DOI:10.1136/bmj.290.6485.1885
PMID:3924299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1416771/
Abstract

Decisions about when to start and stop antiepileptic treatment have important implications for patients with epilepsy. Clinical practice varies and is determined more by dogmatic teaching than by knowledge of either the clinical course of epilepsy or the influence of the drugs. A review of the available evidence shows the need for further studies on the effects of starting and withdrawing treatment on the clinical course and prognosis of epilepsy.

摘要

关于何时开始及停止抗癫痫治疗的决策对癫痫患者具有重要意义。临床实践各不相同，更多地由教条式教学而非对癫痫临床病程或药物影响的了解所决定。对现有证据的综述表明，需要进一步研究开始和停止治疗对癫痫临床病程及预后的影响。

相似文献

1
When do epileptic patients need treatment? Starting and stopping medication.癫痫患者何时需要治疗？药物的起始与停用。
Br Med J (Clin Res Ed). 1985 Jun 22;290(6485):1885-8. doi: 10.1136/bmj.290.6485.1885.
2
[The withdrawal of antiepileptic medication].
Acta Med Port. 1997 Aug-Sep;10(8-9):581-4.
3
[Pharmacological basis for withdrawal of antiepileptic drugs].
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4
[Stopping antiepileptic treatment].
Rev Neurol (Paris). 1990;146(5):380-2.
5
Four-year outcome after early withdrawal of antiepileptic drugs in childhood epilepsy.儿童癫痫患者早期停用抗癫痫药物后的四年随访结果
Neurology. 2005 Jun 28;64(12):2136-8. doi: 10.1212/01.WNL.0000166035.26217.61.
6
A systematic review of antiepileptic drug initiation and withdrawal.抗癫痫药物起始与撤药的系统评价
Neurologist. 2009 May;15(3):122-31. doi: 10.1097/NRL.0b013e3181901ad3.
7
Discontinuing antiepileptic therapy.停用抗癫痫治疗。
Am Fam Physician. 1985 Apr;31(4):177-84.
8
[Prognosis of epilepsy and withdrawal of treatment: withdrawal of treatment in childhood and adolescents].[癫痫的预后与治疗撤药：儿童及青少年期的治疗撤药]
Rev Neurol. 2000;30(4):351-5.
9
Starting and stopping treatment for seizures and epilepsy.癫痫发作和癫痫的治疗启动与停止
Epilepsia. 2006;47 Suppl 1:58-61. doi: 10.1111/j.1528-1167.2006.00662.x.
10
[Discontinuation of antiepileptic drug treatment in controlled seizure patients].[癫痫得到控制的患者停用抗癫痫药物治疗]
Seishin Shinkeigaku Zasshi. 1990;92(6):343-66.

引用本文的文献

1
Postsurgical treatment of epilepsy.癫痫的术后治疗。
Epilepsy Curr. 2004 Jul-Aug;4(4):127-30. doi: 10.1111/j.1535-7597.2004.44001.x.
2
The management of epilepsy in the 1990s. Acquisitions, uncertainties and priorities for future research.20世纪90年代癫痫的管理。未来研究的进展、不确定性和优先事项。
Drugs. 1995 May;49(5):680-94. doi: 10.2165/00003495-199549050-00004.
3
Modern treatment strategies for patients with epilepsy: a review.癫痫患者的现代治疗策略：综述
J R Soc Med. 1991 Mar;84(3):159-62. doi: 10.1177/014107689108400315.
4
Prospects for new drug treatment in epilepsy: a review.癫痫新药治疗的前景：综述
J R Soc Med. 1990 Jun;83(6):383-6. doi: 10.1177/014107689008300616.

本文引用的文献

1
FREQUENCY OF RECURRENCE AFTER DISCONTINUANCE OF ANTI-CONVULSANT THERAPY IN PATIENTS WITH EPILEPTIC SEIZURES.癫痫发作患者停用抗惊厥治疗后的复发频率
Epilepsia. 1964 Dec;5:352-63. doi: 10.1111/j.1528-1157.1964.tb03341.x.
2
Prognosis in convulsive disorders.惊厥性疾病的预后
Arch Neurol. 1959 Aug;1:216-25. doi: 10.1001/archneur.1959.03840020090011.
3
Medical treatment in epilepsy.癫痫的医学治疗。
Br Med J. 1958 Mar 22;1(5072):666-9. doi: 10.1136/bmj.1.5072.666.
4
[Problems and experiences with termination of anticonvulsive therapy].[抗惊厥治疗终止的问题与经验]
Neue Osterr Z Kinderheilkd. 1957;2(2):152-63.
5
Evaluation of standard anticonvulsant therapy in three hundred nineteen patients.对319例患者的标准抗惊厥治疗进行评估。
J Am Med Assoc. 1952 Oct 18;150(7):663-7. doi: 10.1001/jama.1952.03680070033009.
6
The incidence of postoperative seizures.术后癫痫发作的发生率。
Acta Neurochir (Wien). 1981;55(3-4):253-64. doi: 10.1007/BF01808441.
7
Stopping medication in children with epilepsy: predictors of outcome.癫痫患儿停药：预后的预测因素
N Engl J Med. 1981 May 7;304(19):1125-9. doi: 10.1056/NEJM198105073041902.
8
Seizure recurrence after a first unprovoked seizure.首次无诱因发作后的癫痫复发。
N Engl J Med. 1982 Aug 26;307(9):522-8. doi: 10.1056/NEJM198208263070903.
9
Early prognosis of epilepsy.癫痫的早期预后
Br Med J (Clin Res Ed). 1982 Dec 11;285(6356):1699-701. doi: 10.1136/bmj.285.6356.1699.
10
Prognosis in childhood epilepsy: additional follow-up of 148 children 15 to 23 years after withdrawal of anticonvulsant therapy.儿童癫痫的预后：抗惊厥治疗停药15至23年后对148名儿童的额外随访
N Engl J Med. 1982 Apr 8;306(14):831-6. doi: 10.1056/NEJM198204083061403.