癫痫患者的现代治疗策略：综述
Modern treatment strategies for patients with epilepsy: a review.
作者信息
Duncan J S
机构信息
Institute of Neurology, National Hospital for Neurology and Neurosurgery, London.
出版信息
J R Soc Med. 1991 Mar;84(3):159-62. doi: 10.1177/014107689108400315.
Abstract
Of patients who develop epilepsy 70-80% will become seizure free, the remaining 20% are the most difficult to treat satisfactorily. Eighty per cent of patients are best treated with a single drug. Stepwise treatment plans for the treatment of newly diagnosed patients and for the evaluation of patients with chronic epilepsy are suggested. There is a lack of consensus regarding the rate at which to taper antiepileptic drugs being discontinued in patients with active epilepsy. There are arguments for making drug changes rapidly; these arguments and strategies for managing the withdrawal of individual drugs are presented.
摘要
在患癫痫的患者中，70%-80%的人将不再发作，其余20%是最难得到满意治疗的。80%的患者用单一药物治疗效果最佳。文中建议了针对新诊断患者的逐步治疗方案以及慢性癫痫患者的评估方案。对于正在服用抗癫痫药物的活动性癫痫患者，在逐渐减停药物时应以何种速率进行，目前尚无共识。对于快速换药存在一些观点，本文介绍了这些观点以及管理 individual drugs撤药的策略。 （注：原文中“individual drugs”表述不太准确，可能有信息缺失，这里按原文翻译）
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本文引用的文献
1
Anticonvulsant drugs and cognitive functions.抗惊厥药物与认知功能。
Epilepsia. 1982 Oct;23(5):531-44. doi: 10.1111/j.1528-1157.1982.tb05439.x.
2
Removal of sedative-hypnotic antiepileptic drugs from the regimens of patients with intractable epilepsy.从难治性癫痫患者的治疗方案中停用镇静催眠抗癫痫药物。
Ann Neurol. 1983 Mar;13(3):320-4. doi: 10.1002/ana.410130316.
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Two antiepileptic drugs for intractable epilepsy with complex-partial seizures.两种用于治疗伴有复杂部分性发作的顽固性癫痫的抗癫痫药物。
J Neurol Neurosurg Psychiatry. 1982 Dec;45(12):1119-24. doi: 10.1136/jnnp.45.12.1119.
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Sodium valproate: monotherapy and polytherapy.丙戊酸钠：单药治疗与联合治疗
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Effect of reduction of anticonvulsants on wellbeing.减少抗惊厥药物对健康的影响。
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Monotherapy or polytherapy for epilepsy?癫痫的单药治疗还是联合治疗？
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Seizure management with minimal medications in institutionalized mentally retarded epileptics. A prospective study. First report after 4 1/2 years of follow up.在机构收容的智障癫痫患者中使用最少药物进行癫痫发作管理。一项前瞻性研究。随访4年半后的首次报告。
Clin Electroencephalogr. 1983 Jul;14(3):164-72. doi: 10.1177/155005948301400312.
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Rationalisation of therapy in severe epilepsy.重症癫痫治疗的合理化
Aust N Z J Med. 1983 Dec;13(6):601-4. doi: 10.1111/j.1445-5994.1983.tb02612.x.
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Unnecessary polypharmacy in patients with frequent seizures.癫痫频繁发作患者中不必要的联合用药。
Acta Neurol Scand. 1984 Jan;69(1):15-9. doi: 10.1111/j.1600-0404.1984.tb07774.x.
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