Boulogeorgou Kassiani, Topalidis Christos, Koletsa Triantafyllia, Karayannopoulou Georgia, Kanitakis Jean
Laboratory of Pathology, AHEPA University Hospital, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.
Laboratory of Pathology, Lyon-Sud Hospital Center, 69495 Pierre Bénite, France.
Dermatopathology (Basel). 2024 Oct 23;11(4):293-302. doi: 10.3390/dermatopathology11040031.
(Tricho-rhino-phalangeal syndrome 1) is a GATA transcriptional activator gene encoding for a protein used as a sensitive immunohistochemical marker of breast carcinomas. In dermatopathology, TRPS1 is used as a marker of mammary and extramammary Paget's disease and is also expressed by a variety of primary cutaneous tumors, mostly of adnexal origin. So far, very limited data exist on the expression of TRPS1 in metastatic skin tumors. We studied the immunohistochemical expression of TRPS1 in 72 cutaneous metastatic tumors from the breast (n: 19) and other origins (n: 53) in order to assess its diagnostic usefulness. The intensity of TRPS1 immunostaining was expressed as a histoscore: the product of the percentage of positive cells (scored semi-quantitatively 0-4) and the staining intensity (scored 0-3). In normal skin, nuclear TRPS1 expression was predominantly observed in cells of adnexal structures (pilosebaceous follicles and sweat glands). Eighteen (18/19, 94.7%) metastatic breast carcinomas showed diffuse and strong TRPS1 positivity (histoscore 12). Lower reactivity was found in some other metastases, including from the lung (11/22), the female genital tract (3/4), and the kidney (2/4), whereas most (20/22) metastases from the digestive system and peritoneum, along with a case of metastatic prostate carcinoma, were negative. These results suggest that a high histoscore for TRPS1 is in favor of the mammary origin of metastatic cutaneous carcinoma. Although TRPS1 is not absolutely specific or sensitive to a particular primary, we consider that it can be added to a panel of other markers when investigating the origin of a cutaneous metastasis, namely when this is the first manifestation of the neoplastic disease.
（毛发 - 鼻 - 指综合征1型）是一种GATA转录激活基因，编码一种蛋白质，该蛋白质可作为乳腺癌的敏感免疫组织化学标志物。在皮肤病理学中，TRPS1用作乳腺和乳腺外佩吉特病的标志物，也表达于多种原发性皮肤肿瘤，大多起源于附属器。到目前为止，关于TRPS1在转移性皮肤肿瘤中的表达数据非常有限。我们研究了72例皮肤转移性肿瘤（来自乳腺的19例和其他来源的53例）中TRPS1的免疫组织化学表达，以评估其诊断价值。TRPS1免疫染色强度用组织学评分表示：阳性细胞百分比（半定量评分0 - 4）与染色强度（评分0 - 3）的乘积。在正常皮肤中，核TRPS1表达主要见于附属器结构（毛囊皮脂腺和汗腺）的细胞。18例（18/19，94.7%）转移性乳腺癌显示弥漫性且强的TRPS1阳性（组织学评分12）。在其他一些转移瘤中发现较低的反应性，包括来自肺的转移瘤（11/22）、女性生殖道的转移瘤（3/4）和肾的转移瘤（2/4），而大多数来自消化系统和腹膜的转移瘤（20/22）以及1例转移性前列腺癌为阴性。这些结果表明，TRPS1的高组织学评分有利于转移性皮肤癌的乳腺起源。尽管TRPS1对特定原发肿瘤并非绝对特异或敏感，但我们认为在研究皮肤转移瘤的起源时，即当这是肿瘤性疾病的首发表现时，它可以添加到其他标志物组合中。
