The Salk Institute for Biological Studies, La Jolla, CA 92037, USA; John Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT 84112, USA.
Department of Applied Mathematics, Western University, London, ON N6A 3K7, Canada; Brain and Mind Institute, Western University, London, ON N6A 3K7, Canada.
Cell Rep. 2024 Sep 24;43(9):114707. doi: 10.1016/j.celrep.2024.114707. Epub 2024 Sep 6.
Intrinsic cortical activity forms traveling waves that modulate sensory-evoked responses and perceptual sensitivity. These intrinsic traveling waves (iTWs) may arise from the coordination of synaptic activity through long-range feature-dependent horizontal connectivity within cortical areas. In a spiking network model that incorporates feature-selective patchy connections, we observe iTW motifs that result from shifts in excitatory/inhibitory balance as action potentials traverse these patchy connections. To test whether feature-selective motifs occur in vivo, we examined data recorded in the middle temporal visual area (Area MT) of marmosets performing a visual detection task. We find that some iTWs form motifs that are feature selective, exhibiting direction-selective modulations in spiking activity. Further, motifs modulate the gain of target-evoked responses and perceptual sensitivity if the target matches the preference of the motif. These results suggest that iTWs are shaped by the patchy horizontal fiber projections in the cortex and can regulate neural and perceptual sensitivity in a feature-selective manner.
皮质固有活动形成传播波，调节感觉诱发反应和感知敏感性。这些固有传播波（iTWs）可能源于皮质区域内长程特征依赖水平连接的突触活动协调。在一个包含特征选择点状连接的尖峰网络模型中，我们观察到由于动作电位穿越这些点状连接而导致的兴奋/抑制平衡变化产生的 iTW 模式。为了测试特征选择性模式是否存在于体内，我们检查了在执行视觉检测任务的狨猴的中颞视觉区（Area MT）中记录的数据。我们发现，一些 iTWs 形成特征选择性的模式，表现出尖峰活动的方向选择性调制。此外，如果目标与模式的偏好匹配，则模式可以调节目标诱发反应和感知敏感性的增益。这些结果表明，iTWs 是由皮质中的点状水平纤维投射形成的，并且可以以特征选择性的方式调节神经和感知敏感性。
