Department of Otolaryngology, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213004, China.
Department of Otolaryngology, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213004, China.
Mutat Res. 2024 Jul-Dec;829:111882. doi: 10.1016/j.mrfmmm.2024.111882. Epub 2024 Aug 30.
Despite considerable advancements in the diagnosis and treatment of LSCC, there has been no significant improvement in survival rate. Consequently, identifying molecular targets for this cancer is of paramount importance. HOXA1, a constituent of the homeobox transcription factor cluster, plays a role in the development of various types of cancer. Nevertheless, the specific function and mechanism of HOXA1 in LSCC remains unclear. This study aimed to clarify the impact of HOXA1 on the advancement of LSCC and uncover its underlying mechanism. Our findings indicate that HOXA1 exhibits a significantly elevated expression level in LSCC. Suppression of HOXA1 inhibited the proliferation of LSCC cells. Furthermore, the ablation of HOXA1 triggered the apoptosis of LSCC cells and inhibited EMT. Functionally, HOXA1 has a role in initiating the activation of the PI3K/AKT/mTOR pathway in LSCC cells. In summary, HOXA1 significantly contributes to the EMT of LSCC cells via the PI3K/AKT/mTOR signaling pathway, thereby facilitating the proliferation and motility of LSCC cells. Consequently, HOXA1 presents itself as a viable therapeutic target for LSCC interventions.
尽管在 LSCC 的诊断和治疗方面取得了相当大的进展，但生存率并没有显著提高。因此，确定这种癌症的分子靶标至关重要。HOXA1 是同源盒转录因子簇的组成部分，在各种类型的癌症的发展中发挥作用。然而，HOXA1 在 LSCC 中的具体功能和机制尚不清楚。本研究旨在阐明 HOXA1 对 LSCC 进展的影响，并揭示其潜在的机制。我们的研究结果表明，HOXA1 在 LSCC 中表达水平显著升高。抑制 HOXA1 抑制了 LSCC 细胞的增殖。此外，HOXA1 的缺失引发了 LSCC 细胞的凋亡并抑制了 EMT。功能上，HOXA1 可在 LSCC 细胞中启动 PI3K/AKT/mTOR 通路的激活。综上所述，HOXA1 通过 PI3K/AKT/mTOR 信号通路显著促进 LSCC 细胞的 EMT，从而促进 LSCC 细胞的增殖和迁移。因此，HOXA1 为 LSCC 的干预提供了一个可行的治疗靶点。
