Department of Neurology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China; Department of Geriatrics, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China; Key Laboratory of Brain-Machine Intelligence Technology, Ministry of Education, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Neurobiol Dis. 2024 Oct 15;201:106659. doi: 10.1016/j.nbd.2024.106659. Epub 2024 Sep 5.
Parkinson's disease (PD) tremor is associated with dysfunction in the basal ganglia (BG), cerebellum (CB), and sensorimotor networks (SMN). We investigated tremor-related static functional network connectivity (SFNC) and dynamic functional network connectivity (DFNC) in PD patients.
We analyzed the resting-state functional MRI data of 21 tremor-dominant Parkinson's disease (TDPD) patients and 29 healthy controls. We compared DFNC and SFNC between the three networks and assessed their associations with tremor severity.
TDPD patients exhibited increased SFNC between the SMN and BG networks. In addition, they spent more mean dwell time (MDT) in state 2, characterized by sparse connections, and less MDT in state 4, indicating stronger connections. Furthermore, enhanced DFNC between the CB and SMN was observed in state 2. Notably, the MDT of state 2 was positively associated with tremor scores.
The enhanced dynamic connectivity between the CB and SMN in TDPD patients suggests a potential compensatory mechanism. However, the tendency to remain in a state of sparse connectivity may contribute to the severity of tremor symptoms.
帕金森病（PD）震颤与基底节（BG）、小脑（CB）和感觉运动网络（SMN）的功能障碍有关。我们研究了 PD 患者震颤相关的静息态功能网络连接（SFNC）和动态功能网络连接（DFNC）。
我们分析了 21 例震颤为主的帕金森病（TDPD）患者和 29 例健康对照者的静息态功能磁共振成像数据。我们比较了三个网络之间的 DFNC 和 SFNC，并评估了它们与震颤严重程度的关系。
TDPD 患者表现出 SMN 和 BG 网络之间 SFNC 的增加。此外，他们在以稀疏连接为特征的状态 2 中花费更多的平均停留时间（MDT），而在状态 4 中花费更少的 MDT，这表明连接更强。此外，在状态 2 中观察到 CB 和 SMN 之间增强的 DFNC。值得注意的是，状态 2 的 MDT 与震颤评分呈正相关。
TDPD 患者 CB 和 SMN 之间增强的动态连接提示存在潜在的代偿机制。然而，倾向于保持稀疏连接状态可能导致震颤症状的严重程度增加。
