Interdisciplinary Laboratory of Research in Bio-Resources, Environment and Materials, Higher Normal School, Cadi Ayyad University, 40000 Marrakech, Morocco; Univ Rennes, CNRS, ISCR-UMR 6226, F-35000 Rennes, France.
Laboratory of Anthropogenic, Biotechnology and Health, Team physiopathology Nutritional, Neurosciences and Toxicology, Faculty of Sciences, Chouaib Doukkali University, Av. Des facultés, 24000 El Jadida, Morocco.
Int J Biol Macromol. 2024 Nov;279(Pt 3):135356. doi: 10.1016/j.ijbiomac.2024.135356. Epub 2024 Sep 6.
One of the current challenges in targeting neurological disorders is that many therapeutic molecules cannot cross the blood-brain barrier (BBB), which limits the use of natural molecules in nervous tissue regeneration. Thus, the development of new drugs to effectively treat neurological disorders would be a challenge. Natural resources are well known as a source of several therapeutic agents for the treatment of neurologic disorders. Recently, chitosan (CTS) and its derivatives from arthropod exoskeletons, have attracted much attention as a drug delivery system to transport therapeutic substances across the BBB and thanks to other neuroprotective effects including the participation to the CNS regenerations scaffolds to replicate the extracellular matrix and microenvironment of the body. This review will discuss the place of natural resource therapy in targeting neurological disorders. In particular, it will highlight recent understanding and progress in the applications of CTS as drug delivery systems and their therapeutic effects on these disorders through tissue regeneration, as well as the molecular mechanisms by which they exert these effects.
针对神经紊乱的当前挑战之一在于，许多治疗性分子无法穿过血脑屏障（BBB），这限制了天然分子在神经组织再生中的应用。因此，开发能够有效治疗神经紊乱的新药将是一个挑战。天然资源作为治疗神经紊乱的多种治疗药物的来源已广为人知。最近，来自节肢动物外骨骼的壳聚糖（CTS）及其衍生物已引起广泛关注，因为它可以作为一种药物输送系统，将治疗物质穿过 BBB 运输，同时具有其他神经保护作用，包括参与 CNS 再生支架，以复制身体的细胞外基质和微环境。本综述将讨论天然资源治疗在靶向神经紊乱中的作用。特别是，它将突出最近对 CTS 作为药物输送系统的应用的理解和进展，以及它们通过组织再生对这些紊乱的治疗效果，以及它们发挥这些作用的分子机制。
