Binti Md Bahar Ainun Nadzurah, Muhamad Anis Najwa, Teh Cindy Shuan Ju, Adnan Mohamad Shafiq, Adam Shah, Hng Shih Ying, Eg Kah Peng, Nathan Anna Marie
Department of Pediatrics, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
Department of Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
Pathog Glob Health. 2024 Oct-Dec;118(7-8):582-586. doi: 10.1080/20477724.2024.2400412. Epub 2024 Sep 8.
In Malaysia, pertussis in children beyond infancy is underreported. This study aimed to determine the prevalence of and the prevalence of pertussis-susceptible children aged ≥4 years who presented with acute respiratory infections.
This single-center, cross-sectional study conducted at the Paediatric Emergency Department from 1 October 2022, to 31 January 2023, included children aged 4 years and older with ARTIs symptoms and excluded those who were COVID-19 positive. was detected via quantitative Polymerase Chain Reaction on nasopharyngeal swabs and pertussis toxin (PT) IgG enzyme-linked immunosorbent assay.
Children ( = 298) with a median (Interquartile range, [IQR]) age of 6.0 (5.0, 8.0) years old were recruited, and 98% were vaccinated adequately. Two cases of ( = 2/298, 0.67%) were detected. Both children were also co-infected with . The majority of the patients ( = 246/296, 83.1%) had low protective antibodies against pertussis (anti-PT IgG <5 IU/ml), and children 5 years and older were more likely to have lower anti-PT Ig G levels of <5 IU/ml (odds ratio 2.02 [95% CI 1.04,3.90]) compared to children 4 years old.
The prevalence of pertussis was low. However, there is significant waning immunity. Booster doses of pertussis vaccine should be given to all school-aged children.
在马来西亚，婴儿期后的儿童百日咳报告不足。本研究旨在确定4岁及以上出现急性呼吸道感染的儿童中百日咳的患病率以及百日咳易感儿童的患病率。
这项单中心横断面研究于2022年10月1日至2023年1月31日在儿科急诊科进行，纳入了有急性呼吸道感染症状的4岁及以上儿童，并排除了新冠病毒检测呈阳性的儿童。通过对鼻咽拭子进行定量聚合酶链反应检测百日咳杆菌，并采用百日咳毒素（PT）IgG酶联免疫吸附测定法。
招募了年龄中位数（四分位间距，[IQR]）为6.0（5.0，8.0）岁的儿童（n = 298），98%的儿童接种了足够剂量的疫苗。检测到2例百日咳杆菌感染（n = 2/298，0.67%）。这两名儿童还同时感染了其他病原体。大多数患者（n = 246/296，83.1%）对百日咳的保护性抗体水平较低（抗PT IgG <5 IU/ml），与4岁儿童相比，5岁及以上儿童抗PT IgG水平<5 IU/ml的可能性更高（优势比2.02 [95% CI 1.04，3.90]）。
百日咳的患病率较低。然而，免疫力显著下降。应给所有学龄儿童接种百日咳疫苗加强针。
