铅暴露对石斑鱼生理内稳态的毒性作用：从肠道-肝脏轴角度看。
The toxic effect of lead exposure on the physiological homeostasis of grouper: Insight from gut-liver axis.
机构信息
Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture and Rural Affairs, State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510300, PR China; Key Laboratory of Efficient Utilization and Processing of Marine Fishery Resources of Hainan Province, Sanya Tropical Fisheries Research Institute, Sanya 572018, PR China.
Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture and Rural Affairs, State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510300, PR China; Shenzhen Base of South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shenzhen 518121, PR China.
出版信息
Mar Pollut Bull. 2024 Oct;207:116926. doi: 10.1016/j.marpolbul.2024.116926. Epub 2024 Sep 7.
The heavy metal lead (Pb) pollution in marine environment has been widely concerned. The liver and intestine are important for the health of fish. In this study, the grouper were exposed to 1 μg/L Pb for 14 days, and the physiological homeostasis changes were explored via gut-liver axis. The results showed that Pb stress caused liver morphological changes, oxidative stress, and the accumulation and peroxidation of the lipids. The liver metabolism were disturbed, especially amino acid metabolism and the synthesis and degradation of ketone bodies. Pb stress also caused intestinal mucosal ablation, tight junction dysfunction and inflammatory response. Additionally, intestinal microbial diversity was decreased, and the community composition was altered especially several bacteria genera (Ruminococcus UCG-005, Ruminococcus UCG-014, Oscillibacter, and Streptococcus) were significantly correlated with the physiological indexes and metabolites of the liver. These results reveal that Pb stress negatively affect the physiological homeostasis of the grouper via gut-liver axis.
海洋环境中的重金属铅（Pb）污染受到广泛关注。肝脏和肠道是鱼类健康的重要器官。本研究通过肠-肝轴探讨了石斑鱼暴露于 1μg/L Pb 14 天后的生理内稳态变化。结果表明，Pb 胁迫导致肝脏形态发生变化，产生氧化应激，脂质蓄积和过氧化。肝脏代谢受到干扰，特别是氨基酸代谢以及酮体的合成和降解。Pb 胁迫还导致肠道黏膜脱落、紧密连接功能障碍和炎症反应。此外，肠道微生物多样性减少，群落组成发生改变，特别是几个细菌属（瘤胃球菌 UCG-005、瘤胃球菌 UCG-014、拟杆菌属和链球菌属）与肝脏的生理指标和代谢物显著相关。这些结果表明，Pb 胁迫通过肠-肝轴对石斑鱼的生理内稳态产生负面影响。
Zotero 插件