Institute of Radiation Physics, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
Center for Proton Therapy, Paul Scherrer Institute, Villigen PSI, Switzerland; Klinik für Radio-Onkologie, UniversitätsSpital Zürich, Switzerland.
Radiother Oncol. 2024 Nov;200:110507. doi: 10.1016/j.radonc.2024.110507. Epub 2024 Sep 6.
Treatments at ultra-high dose rate (UHDR) have the potential to improve the therapeutic index of radiation therapy (RT) by sparing normal tissues compared to conventional dose rate irradiations. Insufficient and inconsistent reporting in physics and dosimetry of preclinical and translational studies may have contributed to a reproducibility crisis of radiobiological data in the field. Consequently, the development of a common terminology, as well as common recording, reporting, dosimetry, and metrology standards is required. In the context of UHDR irradiations, the temporal dose delivery parameters are of importance, and under-reporting of these parameters is also a concern.This work proposes a standardization of terminology, recording, and reporting to enhance comparability of both preclinical and clinical UHDR studies and and to allow retrospective analyses to aid the understanding of the conditions which give rise to the FLASH effect.
超高剂量率（UHDR）治疗有可能通过与常规剂量率照射相比，保护正常组织，从而提高放射治疗（RT）的治疗指数。临床前和转化研究中的物理和剂量学报告不充分且不一致，这可能导致该领域的放射生物学数据再现性危机。因此，需要制定通用术语以及通用记录、报告、剂量学和计量标准。在 UHDR 照射的情况下，时间剂量传递参数很重要，这些参数的报告不足也是一个问题。这项工作提出了术语、记录和报告的标准化，以提高临床前和临床 UHDR 研究的可比性，并允许进行回顾性分析，以帮助理解产生 FLASH 效应的条件。
