Zhang Zheng
Department of Neurology, Yale University, 333 Cedar Street, New Haven, CT, 06520, USA.
Brain Imaging Behav. 2024 Dec;18(6):1569-1581. doi: 10.1007/s11682-024-00919-1. Epub 2024 Sep 9.
Ischemic stroke is a leading neurological cause of severe disabilities and death in the world and has a major negative impact on patients' quality of life. However, the neural mechanism of spontaneous fluctuating neuronal activity remains unclear. This meta-analysis explored brain activity during resting state in patients with ischemic stroke including 22 studies of regional homogeneity, amplitude of low-frequency fluctuation, and fractional amplitude of low-frequency fluctuation (692 patients with ischemic stroke, 620 healthy controls, age range 35-80 years, 41% female, 175 foci). Results showed decreased regional activity in the bilateral caudate and thalamus and increased regional activity in the left superior occipital gyrus and left default mode network (precuneus/posterior cingulate cortex). Meta-analysis of the amplitude of low-frequency fluctuation studies showed that increased activity in the left inferior frontal gyrus was reduced across the progression from acute to chronic phases. These findings may indicate that disruption of the subcortical areas and default mode network could be one of the core functional abnormalities in ischemic stroke. Altered brain activity in the inferior frontal gyrus could be the imaging indicator of brain recovery/plasticity after stroke damage, which offers potential insight into developing prediction models and therapeutic strategies for ischemic stroke rehabilitation and recovery.
缺血性中风是全球导致严重残疾和死亡的主要神经学原因，对患者的生活质量有重大负面影响。然而，自发波动的神经元活动的神经机制仍不清楚。这项荟萃分析探讨了缺血性中风患者静息状态下的脑活动，包括22项关于局部一致性、低频波动幅度和低频波动分数幅度的研究（692例缺血性中风患者，620例健康对照，年龄范围35 - 80岁，41%为女性，175个病灶）。结果显示双侧尾状核和丘脑的区域活动减少，左侧枕上回和左侧默认模式网络（楔前叶/后扣带回皮质）的区域活动增加。低频波动幅度研究的荟萃分析表明，从急性期到慢性期，左侧额下回的活动增加有所减少。这些发现可能表明皮质下区域和默认模式网络的破坏可能是缺血性中风的核心功能异常之一。额下回脑活动的改变可能是中风损伤后脑恢复/可塑性的影像学指标，这为开发缺血性中风康复和恢复的预测模型及治疗策略提供了潜在的见解。
