Fan Lin, Hu Jun, Ma Wenying, Wang Donghao, Yao Qun, Shi Jingping
Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 21000, China; Department of Neurology, Taizhou People's Hospital, Taizhou, 225300, China.
Department of Radiology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 21000, China.
Neurosci Lett. 2019 Jan 23;692:199-203. doi: 10.1016/j.neulet.2018.11.007. Epub 2018 Nov 12.
The aims of this study were to investigated the changes of brain function and cognitive function in patients with acute posterior cerebellar infarction using the functional magnetic resonance imaging (fMRI) tecniques: fractional amplitude of low-frequency fluctuation (fALFF) and functional connectivity (FC). Forty acute cerebellar infarction patients and 40 healthy controls were included. The differences of fALFF were compared. The regions showed significant differences were set as regions of interest (ROIs), and then the FC values between ROIs and the whole brain were analysed. Pearson correlation analysis was used to understand the correlation between FC values and cognitive function scores. The results showed significant group differences in fALFF values in the four brain regions, including the right frontal lobe, left hippocampus, right cingulate gyrus and cerebellum posterior lobe. Pearson correlation analysis suggested that abnormal alterations in the left hippocampus and right cingulate gyrus may play a core role in the cognitive impairment associated with cerebellar infarction. The changes of fALFF and FC values in related brain area from cerebellar stroke complement and enrich our understanding of cerebellar involvement in cognition involved in cognitive performance.
本研究旨在使用功能磁共振成像（fMRI）技术：低频振幅分数（fALFF）和功能连接（FC），研究急性小脑后梗死患者的脑功能和认知功能变化。纳入40例急性小脑梗死患者和40例健康对照。比较fALFF的差异。将显示出显著差异的区域设定为感兴趣区域（ROIs），然后分析ROIs与全脑之间的FC值。采用Pearson相关分析来了解FC值与认知功能评分之间的相关性。结果显示，在四个脑区，包括右侧额叶、左侧海马体、右侧扣带回和小脑后叶，fALFF值存在显著的组间差异。Pearson相关分析表明，左侧海马体和右侧扣带回的异常改变可能在与小脑梗死相关的认知障碍中起核心作用。小脑卒中共相关脑区fALFF和FC值的变化补充并丰富了我们对小脑参与认知表现的认识。
