Research Laboratory for Analytical Instrument and Electrochemistry Innovation, Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand.
Research Laboratory on Advanced Materials for Sensor and Biosensor Innovation, Materials Science Research Center, Center of Excellence for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand.
Anal Methods. 2024 Oct 3;16(38):6474-6486. doi: 10.1039/d4ay01429d.
Metal-Organic Frameworks (MOFs) have garnered significant attention in the development of electrochemical glucose sensors due to their unique and advantageous properties. The highly tunable pore channels of MOFs facilitate optimal diffusion of glucose molecules, while their large specific surface area provides abundant active sites for electrochemical reactions. Furthermore, the well-dispersed metallic active sites within MOFs enhance electrocatalytic activity, thereby improving the sensitivity and selectivity of glucose detection. These features make MOF-based nanoarchitectures promising candidates for the development of efficient and sensitive glucose sensors, which are crucial for diabetes management and monitoring. The integration of enzymatic biosensors with nanotechnology continues to drive advancements in glucose monitoring, offering the potential for more accurate, convenient, and user-friendly tools for diabetes management. Current research explores non-invasive glucose monitoring methods, such as using sweat, saliva, or interstitial fluid instead of blood, aiming to reduce the discomfort and inconvenience associated with frequent blood sampling. A review of the advancements and applications of MOF-based enzyme-mimic electrochemical sensors for glucose monitoring can provide valuable insights for young researchers, inspiring future research in biomedical device fabrication. Such reviews not only offer a comprehensive understanding of the current state of the art but also highlight existing challenges and future opportunities in the field of enzyme-less glucose sensing, particularly in the surface modification techniques of highly porous MOFs. This fosters innovation and new research directions. By understanding the advantages, challenges, and opportunities, researchers can contribute to the development of more effective and innovative enzyme-mimic glucose sensing transducers, which are essential for advancing biomedical devices.
金属有机骨架（MOFs）因其独特和有利的特性，在电化学葡萄糖传感器的开发中引起了极大的关注。MOFs 的高度可调孔道促进了葡萄糖分子的最佳扩散，而其大的比表面积为电化学反应提供了丰富的活性位点。此外，MOFs 内分散良好的金属活性位点增强了电催化活性，从而提高了葡萄糖检测的灵敏度和选择性。这些特点使得基于 MOF 的纳米结构成为开发高效和敏感葡萄糖传感器的有前途的候选者，这对于糖尿病的管理和监测至关重要。酶生物传感器与纳米技术的结合继续推动着葡萄糖监测的进展，为糖尿病管理提供了更准确、方便和用户友好的工具的潜力。目前的研究探索了非侵入性的葡萄糖监测方法，例如使用汗液、唾液或间质液代替血液，旨在减少与频繁采血相关的不适和不便。对基于 MOF 的酶模拟电化学传感器用于葡萄糖监测的进展和应用的综述，可以为年轻研究人员提供有价值的见解，激发生物医学器件制造领域的未来研究。这样的综述不仅提供了对当前艺术状态的全面理解，还突出了无酶葡萄糖传感领域存在的挑战和未来机遇，特别是在高度多孔 MOFs 的表面修饰技术方面。这促进了创新和新的研究方向。通过了解优势、挑战和机遇，研究人员可以为更有效的和创新的酶模拟葡萄糖传感换能器的开发做出贡献，这对于推进生物医学器件至关重要。
