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血管内吲哚菁绿增强近红外荧光血管内超声成像评估切除的人冠状动脉中的进展性动脉粥样硬化病变。

Intravascular ICG-enhanced NIRF-IVUS imaging to assess progressive atherosclerotic lesions in excised human coronary arteries.

作者信息

Rauschendorfer Philipp, Lenz Tobias, Nicol Philipp, Wild Léa, Beele Alicia, Sabic Emina, Klosterman Grace, Laugwitz Karl-Ludwig, Jaffer Farouc A, Gorpas Dimitris, Joner Michael, Ntziachristos Vasilis

机构信息

Chair of Biological Imaging at the Central Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany.

Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany.

出版信息

NPJ Cardiovasc Health. 2024;1(1):14. doi: 10.1038/s44325-024-00016-8. Epub 2024 Aug 30.

DOI:10.1038/s44325-024-00016-8
PMID:39246665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11378621/
Abstract

Indocyanine green (ICG)-enhanced intravascular near-infrared fluorescence (NIRF) imaging enhances the information obtained with intravascular ultrasound (IVUS) by visualizing pathobiological characteristics of atherosclerotic plaques. To advance our understanding of this hybrid method, we aimed to assess the potential of NIRF-IVUS to identify different stages of atheroma progression by characterizing ICG uptake in human pathological specimens. After excision, 15 human coronary specimens from 13 adult patients were ICG-perfused and imaged with NIRF-IVUS. All specimens were then histopathologically and immunohistochemically assessed. NIRF-IVUS imaging revealed colocalization of ICG-deposition to plaque areas of lipid accumulation, endothelial disruption, neovascularization and inflammation. Moreover, ICG concentrations were significantly higher in advanced coronary artery disease stages ( < 0.05) and correlated significantly to plaque macrophage burden ( = 0.67). Current intravascular methods fail to detect plaque biology. Thus, we demonstrate how human coronary atheroma stage can be assessed based on pathobiological characteristics uniquely captured by ICG-enhanced intravascular NIRF.

摘要

吲哚菁绿（ICG）增强型血管内近红外荧光（NIRF）成像通过可视化动脉粥样硬化斑块的病理生物学特征，增强了血管内超声（IVUS）所获得的信息。为了加深我们对这种混合方法的理解，我们旨在通过表征ICG在人类病理标本中的摄取情况，评估NIRF-IVUS识别动脉粥样硬化进展不同阶段的潜力。切除后，对来自13名成年患者的15个人类冠状动脉标本进行ICG灌注并用NIRF-IVUS成像。然后对所有标本进行组织病理学和免疫组织化学评估。NIRF-IVUS成像显示ICG沉积与脂质积聚、内皮破坏、新生血管形成和炎症的斑块区域共定位。此外，在晚期冠状动脉疾病阶段，ICG浓度显著更高（<0.05），并且与斑块巨噬细胞负荷显著相关（=0.67）。目前的血管内方法无法检测斑块生物学特性。因此，我们展示了如何基于ICG增强型血管内NIRF独特捕获的病理生物学特征来评估人类冠状动脉粥样硬化阶段。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6021/11378621/2a8c26748463/44325_2024_16_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6021/11378621/88466257e9f9/44325_2024_16_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6021/11378621/e81029fc6764/44325_2024_16_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6021/11378621/21b67d86a80c/44325_2024_16_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6021/11378621/c6c84dad9b85/44325_2024_16_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6021/11378621/2a8c26748463/44325_2024_16_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6021/11378621/88466257e9f9/44325_2024_16_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6021/11378621/e81029fc6764/44325_2024_16_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6021/11378621/21b67d86a80c/44325_2024_16_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6021/11378621/c6c84dad9b85/44325_2024_16_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6021/11378621/2a8c26748463/44325_2024_16_Fig5_HTML.jpg

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