The effects of physiological state and plane of nutrition on the concentrations of microsomal cytochromes and the omega-oxidation of fatty acids in various tissues of the sheep (Ovis aries).

The omega-oxidation activities and electron transport components of the microsomal fractions of tissues from pregnant, non-pregnant and lactating sheep on different planes of nutrition have been examined. Differences from the rat system were found, and between the non-pregnant and late pregnant sheep. The hepatic microsomal activity of omega-oxidation was approximately doubled by fasting for 5 days, but was unaltered by pregnancy or lactation per se. This increase was not caused by an increase in the specific activity of the omega-hydroxy fatty acid dehydrogenases. The results are discussed in relation to the glucose stresses of pregnancy in ruminants.