Minshull M, Strong C R
Int J Biochem. 1985;17(4):529-32. doi: 10.1016/0020-711x(85)90151-x.
The direct effects of a physiological concentration of corticosterone (50 ng ml-1) in presence of insulin (200 microU ml-1) on lipid synthesis and CO2 production from glucose and glycerol release were evaluated in vitro in white adipose tissue after pre-incubation with the hormones. Lipid synthesis was 27% higher after 24 h and 66% higher after 48h pre-incubation with corticosterone and insulin compared with insulin alone. Basal and adrenaline-stimulated glycerol release and CO2 production were unchanged after pre-incubation with both hormones compared with insulin alone. We propose that corticosterone acts as a pro-lipogenic hormone on adipose tissue in the fed rat, in contrast to its glucose sparing effects in the fasted animal.
在激素预孵育后，于体外评估生理浓度的皮质酮（50 ng/ml）在胰岛素（200 μU/ml）存在的情况下对白色脂肪组织中脂质合成、葡萄糖产生二氧化碳以及甘油释放的直接影响。与单独使用胰岛素相比，在与皮质酮和胰岛素预孵育24小时后，脂质合成增加了27%，48小时后增加了66%。与单独使用胰岛素相比，在两种激素预孵育后，基础和肾上腺素刺激的甘油释放以及二氧化碳产生均未改变。我们提出，与皮质酮在禁食动物中的葡萄糖节省作用相反，它在进食大鼠的脂肪组织中作为一种促脂肪生成激素起作用。
