Giannakaki Aikaterini-Gavriela, Giannakaki Maria-Nektaria, Oikonomou Efthymios, Nikolettos Konstantinos, Bothou Anastasia, Kotanidou Sonia, Andreou Sotiris, Kritsotaki Nektaria, Nalmpanti Theopi, Spanoudakis Emmanuel, Iatrakis George, Damaskos Christos, Garmpis Nikolaos, Nikolettos Nikolaos, Tsikouras Panagiotis
First Department of Obstetrics and Gynecology, Alexandra University Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Department of Internal Medicine, Thriasio General Hospital of Elefsina, 19018 Magoula, Greece.
Mol Clin Oncol. 2024 Aug 21;21(5):79. doi: 10.3892/mco.2024.2777. eCollection 2024 Nov.
The present study aimed to evaluate the epidemiological, diagnostic and therapeutic data of hematological malignancies in pregnancy. Leukemia in pregnancy is rare, and literature data are not extensive. Risk factors, epidemiology and pathogenesis of these diseases are not fully developed. Furthermore, there is a detailed report on the complications in pregnancy and the overall (per trimester) management of these diseases, specifically their treatment strategy. The possibility of achieving a future pregnancy in women with leukemia is described in the present study. The limited clinical research data currently available is mainly due to the inability to conduct randomized clinical trials for ethical reasons. Further research is needed, firstly due to the importance of these diseases for the pregnant woman and the fetus, and secondly, due to the continuous development of novel anticancer drugs that aim to improve the prognosis of these diseases.
本研究旨在评估妊娠期间血液系统恶性肿瘤的流行病学、诊断和治疗数据。妊娠合并白血病较为罕见，文献资料并不丰富。这些疾病的危险因素、流行病学及发病机制尚未完全明确。此外，关于妊娠并发症以及这些疾病的整体（按孕期）管理，特别是其治疗策略，目前尚无详细报道。本研究描述了白血病女性未来妊娠的可能性。目前可用的临床研究数据有限，主要是由于出于伦理原因无法进行随机临床试验。鉴于这些疾病对孕妇和胎儿的重要性，以及旨在改善这些疾病预后的新型抗癌药物不断涌现，进一步的研究很有必要。
