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Neuraxial Analgesia for Scoliosis Correction: A Case Series in a Specialised Children's Centre.用于脊柱侧弯矫正的神经轴镇痛:一家专业儿童中心的病例系列
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本文引用的文献

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Efficacy and safety of intravenous dexmedetomidine as an adjuvant to general anesthesia in gynecological surgeries: A systematic review and meta-analysis of randomized controlled trials.静脉注射右美托咪定作为妇科手术全身麻醉辅助药物的有效性和安全性:一项随机对照试验的系统评价和荟萃分析
Taiwan J Obstet Gynecol. 2023 Mar;62(2):239-251. doi: 10.1016/j.tjog.2022.11.010.
2
Effect of Epidural Dexmedetomidine as an Adjuvant to Local Anesthetics for Labor Analgesia: A Meta-Analysis of Randomized Controlled Trials.硬膜外右美托咪定作为局部麻醉药辅助用于分娩镇痛的效果:一项随机对照试验的荟萃分析
Evid Based Complement Alternat Med. 2021 Oct 27;2021:4886970. doi: 10.1155/2021/4886970. eCollection 2021.
3
Effect of Intravenous Dexmedetomidine on Spinal Anesthesia.静脉注射右美托咪定对脊髓麻醉的影响。
Cureus. 2021 Jun 17;13(6):e15708. doi: 10.7759/cureus.15708. eCollection 2021 Jun.
4
Effects of Three Different Doses of Dexmedetomidine and Ropivacaine on Analgesia and the Stress Response in Hypospadias Surgery: A Randomized Trial.三种不同剂量右美托咪定与罗哌卡因对尿道下裂手术镇痛及应激反应的影响:一项随机试验
Front Pharmacol. 2021 Apr 30;12:612216. doi: 10.3389/fphar.2021.612216. eCollection 2021.
5
Dexmedetomidine reduces postoperative cognitive and behavioral dysfunction in adults submitted to general anesthesia for non-cardiac surgery: meta-analysis of randomized clinical trials.右美托咪定可降低非心脏手术全身麻醉成人术后认知和行为功能障碍:随机临床试验的荟萃分析。
Braz J Anesthesiol. 2021 Jul-Aug;71(4):413-420. doi: 10.1016/j.bjane.2021.02.020. Epub 2021 Feb 19.
6
Caudal dexmedetomidine in pediatric caudal anesthesia: A systematic review and meta-analysis of randomized controlled trials.小儿骶管麻醉中使用尾侧右美托咪定:一项随机对照试验的系统评价和荟萃分析
Medicine (Baltimore). 2020 Jul 31;99(31):e21397. doi: 10.1097/MD.0000000000021397.
7
Dexmedetomidine for the prevention of emergence delirium and postoperative behavioral changes in pediatric patients with sevoflurane anesthesia: a double-blind, randomized trial.右美托咪定预防小儿七氟醚麻醉苏醒期谵妄及术后行为改变:一项双盲随机试验
Drug Des Devel Ther. 2019 Mar 15;13:897-905. doi: 10.2147/DDDT.S196075. eCollection 2019.
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Postoperative pain management in patients undergoing posterior spinal fusion for adolescent idiopathic scoliosis: a narrative review.青少年特发性脊柱侧弯后路脊柱融合术患者的术后疼痛管理:一项叙述性综述
Scoliosis Spinal Disord. 2018 Sep 12;13:17. doi: 10.1186/s13013-018-0165-z. eCollection 2018.
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Dexmedetomidine and general anesthesia: a narrative literature review of its major indications for use in adults undergoing non-cardiac surgery.右美托咪定与全身麻醉:一项针对非心脏手术成人主要适应证的综述性文献研究。
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10
Efficacy and Safety of Dexmedetomidine as an Adjuvant in Epidural Analgesia and Anesthesia: A Systematic Review and Meta-analysis of Randomized Controlled Trials.右美托咪定作为硬膜外镇痛和麻醉辅助药物的疗效与安全性:随机对照试验的系统评价和荟萃分析
Clin Drug Investig. 2017 Apr;37(4):343-354. doi: 10.1007/s40261-016-0477-9.

用于脊柱侧弯矫正的神经轴镇痛:一家专业儿童中心的病例系列

Neuraxial Analgesia for Scoliosis Correction: A Case Series in a Specialised Children's Centre.

作者信息

Alselaiti Abdulrahman A, Muawad Rayan, Mahmoud Ahmed Haroun M, Alzughaibi Nezar M, ALsaad Ahmed, Almashari Yasser, Alneami Ali, Abuareef Saeed

机构信息

Department of Pediatric Anaesthesia, King Abdulaziz Medical City, Riyadh, SAU.

Department of Anesthesiology, King Abdulaziz Medical City, Riyadh, SAU.

出版信息

Cureus. 2024 Aug 7;16(8):e66344. doi: 10.7759/cureus.66344. eCollection 2024 Aug.

DOI:10.7759/cureus.66344
PMID:39246907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11377912/
Abstract

Surgical correction of spinal deformities in children presents a challenge to the anaesthetist due to the extensive nature of the surgery, the co-morbidities of the patients and the constraints on aesthetic techniques of intraoperative neurophysiological monitoring of the spinal cord. Patients undergoing scoliosis surgery are considered to suffer severe pain, which may lead to a negative impact on patient psychology and physical well-being. By using effective postoperative pain regimens to enhance recovery after surgery, pain can be significantly reduced, leading to patient satisfaction, facilitating early mobilisation, promoting oral intake, lowering postoperative pain and shortening the length of hospital stay. Thus, the primary objectives of this study were to assess the postoperative pain management and first rescue analgesic medications, by using preservative-free morphine 50 mcg/kg and dexmedetomidine 4 mcg along with normal saline 0.5 ml kg caudally, as well as to look for the secondary objectives side effects, including respiratory depression, nausea, vomiting and pruritis, timing of postoperative ambulation and length of hospital stay.  Methods: In this study, we retrospectively included children under 14 years of age and above three years who underwent scoliosis surgery under a caudal epidural-general anaesthesia using caudal morphine and the dexmedetomidine technique in the period from January to May 2023 at the National Guard Health Affairs Hospital (NGHA), Riyadh. We collected the data of seven cases using the electronic chart system of the Best Care database to extract the specific cases that meet the inclusion criteria for the study, which are idiopathic scoliosis patients, aged 3-14 years, and primary correction procedures.  Results: The pain-free duration was between seven hours and 48 hours (about two days). There were four female cases (57.14%), and three cases were male (42.85%). The patients' American Society of Anesthesiologists (ASA) status were II to III. In all the cases, there was no documentation of any episodes of postoperative nausea and vomiting (PONV), respiratory distress or pruritus, except for one case where the patient had an episode of PONV.  Conclusion: In this study, our aim was to present our experience with dexmedetomidine as an efficient medication when coadministered with morphine to be used in the operating room. We found a high level of reliability in prolonging analgesia time and delaying the usage of rescue medication. We encourage more studies on caudal dexmedetomidine for patients undergoing scoliosis surgery.

摘要

由于手术范围广、患者合并症以及脊髓术中神经生理监测美学技术的限制,儿童脊柱畸形的手术矫正对麻醉师来说是一项挑战。接受脊柱侧弯手术的患者被认为会遭受剧痛,这可能会对患者的心理和身体健康产生负面影响。通过采用有效的术后疼痛管理方案来促进术后恢复,可以显著减轻疼痛,提高患者满意度,促进早期活动,增加口服摄入量,减轻术后疼痛并缩短住院时间。因此,本研究的主要目的是评估术后疼痛管理和首次急救镇痛药物,通过使用不含防腐剂的吗啡50 mcg/kg和右美托咪定4 mcg以及0.5 ml/kg生理盐水尾端给药,同时寻找包括呼吸抑制、恶心、呕吐和瘙痒等副作用、术后下床活动时间和住院时间等次要目标。方法:在本研究中,我们回顾性纳入了2023年1月至5月在利雅得国民警卫队卫生事务医院(NGHA)接受尾端硬膜外-全身麻醉、采用尾端吗啡和右美托咪定技术进行脊柱侧弯手术的14岁以下且3岁以上的儿童。我们使用最佳护理数据库的电子病历系统收集了7例病例的数据,以提取符合研究纳入标准的特定病例,即特发性脊柱侧弯患者,年龄3 - 14岁,以及初次矫正手术。结果:无痛持续时间在7小时至48小时(约两天)之间。有4例女性病例(57.14%),3例男性病例(42.85%)。患者的美国麻醉医师协会(ASA)分级为II至III级。在所有病例中,除1例患者发生术后恶心呕吐(PONV)外,没有记录到任何术后恶心呕吐、呼吸窘迫或瘙痒的发作。结论:在本研究中,我们的目的是介绍我们在手术室中将右美托咪定与吗啡联合使用时作为一种有效药物的经验。我们发现在延长镇痛时间和延迟使用急救药物方面具有高度可靠性。我们鼓励对接受脊柱侧弯手术的患者进行更多关于尾端右美托咪定的研究。