Verma Kritin K, Matthew Ethan, Deligonul Fatma Z, Blegen Kristina, Tarbox Michelle
Medicine, Texas Tech University Health Sciences Center, Lubbock, USA.
Dermatology, Texas Tech University Health Sciences Center, Lubbock, USA.
Cureus. 2024 Aug 8;16(8):e66470. doi: 10.7759/cureus.66470. eCollection 2024 Aug.
We present a unique case of an 89-year-old male with Alzheimer's disease who developed hemorrhagic blisters on his palms, which ruptured with time and were followed by pruritic erythematous lesions across his chest, upper back, lower abdomen, and thighs. The patient was diagnosed with dyshidrosiform bullous pemphigoid (DBP), an uncommon variant of the autoimmune condition bullous pemphigoid characterized by cutaneous and mucosal blistering, which commonly appears as vesiculobullous eruptions in the palmoplantar areas and may spread to other parts of the body. Less than 100 cases of DBP have been documented in the medical literature. Since DBP is difficult to identify and treat due to its clinical appearance similar to pompholyx, we reviewed the treatment of DBP and included clinical images and direct immunofluorescence (DIF) staining technique images to better establish the diagnosis.
我们报告了一例独特病例，一名89岁患有阿尔茨海默病的男性，其手掌出现出血性水疱，水疱随时间破裂，随后胸部、上背部、下腹部和大腿出现瘙痒性红斑病变。该患者被诊断为汗疱状大疱性类天疱疮（DBP），这是自身免疫性疾病大疱性类天疱疮的一种罕见变体，其特征为皮肤和黏膜水疱形成，通常表现为掌跖部位的水疱大疱性皮疹，并可能扩散至身体其他部位。医学文献中记录的DBP病例不到100例。由于DBP的临床表现与汗疱疹相似，难以识别和治疗，我们回顾了DBP的治疗方法，并纳入临床图像和直接免疫荧光（DIF）染色技术图像，以更好地确诊。
