Yang Xinyu, Yang Xiumin
Department of Dermatology, Beijing Tongren Hospital, Capital Medical University, Beijing, People's Republic of China.
Clin Cosmet Investig Dermatol. 2024 Sep 3;17:1981-1983. doi: 10.2147/CCID.S473442. eCollection 2024.
Sporotrichosis is a common chronic fungal infection and the clinical manifestations are often untypical. Diagnosis of sporotrichosis relies conventionally on fungal culture, histopathological examination, and species identification by molecular test. We reported that a 70-year-old man presented with a cutaneous lesion on the back of his right hand (present for 6 months). The cutaneous bacterial infection was diagnosed at a local hospital and the lesion had not improved. Physical examination revealed an infiltrative reddish plaque with purulent secretion and crusts. Histopathological examination revealed scattered round yeast cells in the dermis. Fungal culture revealed multiple, velvety, brown colonies on Sabouraud dextrose agar (SDA). was identified by PCR-sequencing and next generation sequencing (NGS) method. Finally, a case of sporotrichosis caused by was diagnosed by histopathological examination, mycological examination, and molecular identification. The patient was treated with oral itraconazole 400 mg/day for 2 months. The lesion was dramatically ameliorated.
孢子丝菌病是一种常见的慢性真菌感染，临床表现常不典型。孢子丝菌病的诊断传统上依赖于真菌培养、组织病理学检查以及通过分子检测进行菌种鉴定。我们报告了一名70岁男性，其右手背部出现皮肤损害（已存在6个月）。在当地医院诊断为皮肤细菌感染，皮损未见好转。体格检查发现一个浸润性红色斑块，有脓性分泌物和痂皮。组织病理学检查显示真皮内散在圆形酵母细胞。真菌培养在沙氏葡萄糖琼脂（SDA）上显示多个天鹅绒样棕色菌落。通过聚合酶链反应测序和二代测序（NGS）方法进行鉴定。最后，通过组织病理学检查、真菌学检查和分子鉴定确诊为由[具体菌种]引起的一例孢子丝菌病。该患者接受口服伊曲康唑400毫克/天治疗2个月。皮损明显改善。
