Shaikh Ayesha, Williams David M, Stephens Jeffrey W, Edwards Rhodri
Department of Diabetes and Endocrinology, Morriston Hospital, Swansea Bay University Health Board, Swansea, UK.
Diabetes Research Group, Swansea University Medical School, Swansea University, Swansea, UK.
Eur J Case Rep Intern Med. 2024 Sep 3;11(9):004830. doi: 10.12890/2024_004830. eCollection 2024.
Starvation ketoacidosis represents one of the three forms of metabolic acidosis caused by the accumulation of ketone bodies within the blood stream. It can be easily missed in patients who present acutely and are found to have an unexplained or profound metabolic acidosis. Here, we present a life-threatening case of severe ketoacidosis in a breast-feeding mother without diabetes who was on a strict ketogenic diet. Although a ketogenic diet has been previously considered to be safe in non-pregnant individuals, its safety in breast-feeding mothers in the post-partum period is less known and may be associated with greater harm. Health professionals and mothers should be aware of the potential risks associated with a strict ketogenic diet when combined with breast-feeding, especially in the earlier stages of the post-partum period. Prompt investigation, diagnosis and immediate management is vital to avoid life-threatening complications. We report a case admitted on the acute medical take with starvation ketoacidosis associated with ketogenic diet and adequate calorie consumption who was breast-feeding at the time of admission.
Always check ketones in patients with an unexplained metabolic acidosis; there can be overlap between starvation, alcohol-related and lactic acidosis.Management of starvation ketoacidosis is often empirical, involving close monitoring of fluid status and electrolytes.Clinicians should discuss the risk of ketoacidosis associated with the ketogenic diet in women who plan to breast-feed and lose weight following pregnancy.
饥饿性酮症酸中毒是由酮体在血流中蓄积引起的三种代谢性酸中毒形式之一。在急性发病且被发现有无法解释的或严重代谢性酸中毒的患者中,这种情况很容易被漏诊。在此,我们报告一例危及生命的严重酮症酸中毒病例,患者为一位非糖尿病的哺乳期母亲,她正在严格遵循生酮饮食。尽管生酮饮食以前被认为在非孕妇中是安全的,但其在产后哺乳期母亲中的安全性鲜为人知,且可能带来更大危害。卫生专业人员和母亲们应该意识到,严格的生酮饮食与母乳喂养相结合时存在的潜在风险,尤其是在产后早期阶段。迅速进行检查、诊断和立即处理对于避免危及生命的并发症至关重要。我们报告一例因饥饿性酮症酸中毒伴生酮饮食及充足热量摄入而入住急性内科病房的病例,患者入院时正在哺乳。
对于不明原因代谢性酸中毒的患者,始终要检查酮体;饥饿性、酒精相关性和乳酸酸中毒之间可能存在重叠。饥饿性酮症酸中毒的治疗通常是经验性的,包括密切监测液体状态和电解质。临床医生应该与计划在产后母乳喂养并减肥的女性讨论生酮饮食相关的酮症酸中毒风险。