奥美拉唑对人体内在因子、胃酸及胃蛋白酶分泌的影响。
Effect of omeprazole on the secretion of intrinsic factor, gastric acid and pepsin in man.
作者信息
Kittang E, Aadland E, Schjønsby H
出版信息
Gut. 1985 Jun;26(6):594-8. doi: 10.1136/gut.26.6.594.
Abstract
The effect of an intravenous infusion of omeprazole (0.35 mg/kg) and placebo on basal and stimulated (pentagastrin 1.0 microgram/kg/h) secretion of gastric acid, intrinsic factor and pepsin was studied in 10 healthy male subjects. Omeprazole caused a marked inhibition of basal and stimulated acid output. The inhibition of pepsin output was less marked, but also significant. The output of intrinsic factor, however, showed no significant change. The results indicate that acid and intrinsic factor might have different secretory mechanisms within the parietal cell.
摘要
在10名健康男性受试者中研究了静脉输注奥美拉唑（0.35毫克/千克）和安慰剂对胃酸、内因子和胃蛋白酶基础分泌及刺激分泌（五肽胃泌素1.0微克/千克/小时）的影响。奥美拉唑显著抑制基础和刺激后的胃酸分泌。胃蛋白酶分泌的抑制作用不那么显著，但也具有统计学意义。然而，内因子的分泌没有显著变化。结果表明，酸和内因子在壁细胞内可能具有不同的分泌机制。
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本文引用的文献
1
INVESTIGATIONS ABOUT THE SITE OF PRODUCTION OF CASTLE'S GASTRIC INTRINSIC FACTOR.关于卡斯尔胃内因子产生部位的研究
Lab Invest. 1964 Nov;13:1394-9.
2
Physiology and pathology of vitamin B12 absorption, distribution, and excretion.维生素B12吸收、分布及排泄的生理学与病理学
Adv Clin Chem. 1960;3:299-366.
3
Effect of cimetidine on the absorption of vitamin B12.
Scand J Gastroenterol. 1982 Jan;17(1):129-31. doi: 10.3109/00365528209181056.
4
Effect of omeprazole--a gastric proton pump inhibitor--on pentagastrin stimulated acid secretion in man.奥美拉唑（一种胃质子泵抑制剂）对人五肽胃泌素刺激的胃酸分泌的影响。
Gut. 1983 Apr;24(4):270-6. doi: 10.1136/gut.24.4.270.
5
Histamine H2 receptors and intrinsic factor secretion.组胺H2受体与内因子分泌
Scand J Gastroenterol. 1980;15(3):377-84. doi: 10.3109/00365528009181487.
6
Effect of omeprazole on gastric secretion in H+,K+-ATPase and in pepsinogen-rich cell fractions from rabbit gastric mucosa.奥美拉唑对兔胃黏膜H⁺，K⁺ -ATP酶及富含胃蛋白酶原细胞组分中胃酸分泌的影响。
Biochem Pharmacol. 1984 Jan 15;33(2):273-80. doi: 10.1016/0006-2952(84)90485-4.
7
Effect of substituted benzimidazoles on acid secretion in isolated and enriched guinea pig parietal cells.取代苯并咪唑对分离和富集的豚鼠壁细胞酸分泌的影响。
Gut. 1983 Jun;24(6):557-60. doi: 10.1136/gut.24.6.557.
8
Inhibition of gastric (H+ + K+)-ATPase by the substituted benzimidazole, picoprazole.取代苯并咪唑类药物匹考拉唑对胃（H⁺+K⁺）-ATP酶的抑制作用
Biochim Biophys Acta. 1983 Feb 9;728(1):31-8. doi: 10.1016/0005-2736(83)90433-9.
9
Inhibition of acid secretion in isolated gastric glands by substituted benzimidazoles.取代苯并咪唑对离体胃腺酸分泌的抑制作用。
Am J Physiol. 1982 Dec;243(6):G505-10. doi: 10.1152/ajpgi.1982.243.6.G505.
10
Effects of substituted benzimidazole (H 149/94) on gastric acid secretion in humans.取代苯并咪唑（H 149/94）对人体胃酸分泌的影响。
Gastroenterology. 1982 Jul;83(1 Pt 2):193-8.
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