Chien Yi-Chung, Lee Hsiang-Lin, Chiang Whei-Ling, Bai Li-Yuan, Hung Yu-Ju, Chen Shuo-Chueh, Wang Hsiang-Ling, Yang Shun-Fa, Yu Yung-Luen
Institute of Translational Medicine and New Drug Development, China Medical University, Taichung 40402, Taiwan.
Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
J Cancer. 2024 Aug 13;15(16):5183-5190. doi: 10.7150/jca.98520. eCollection 2024.
Hepatocellular carcinoma (HCC), a major form of liver cancer, is characterized by high lethality and a multifactorial etiology that includes hepatitis virus infections, lifestyle factors, and genetic predispositions. This study aimed to explore the impact of gene polymorphisms on the clinicopathological features of Taiwanese HCC patients, focusing on three specific single nucleotide polymorphisms (SNPs): rs2188971, rs2188972, and rs8105767. Our cohort consisted of 438 HCC patients and 1193 control individuals. Clinical staging was determined using the tumor/node/metastasis (TNM) system, and various clinical indicators were collected. Our analysis revealed a statistically significant increase in expression in HCC patients compared to controls, indicating a potential role in HCC progression. Although no substantial association was observed between SNPs and increased HCC risk, specific clinical features such as distant metastasis and vascular invasion showed significant associations with these SNPs, suggesting their influence on disease aggressiveness. Demographic analyses highlighted the importance of factors like alcohol consumption and viral hepatitis markers in HCC. Our study underscores the complexity of genetic influences on HCC, with polymorphisms potentially affecting tumor progression and patient outcomes.
肝细胞癌（HCC）是肝癌的主要形式，其特点是致死率高且病因多因素，包括肝炎病毒感染、生活方式因素和遗传易感性。本研究旨在探讨基因多态性对台湾HCC患者临床病理特征的影响，重点关注三个特定的单核苷酸多态性（SNP）：rs2188971、rs2188972和rs8105767。我们的队列包括438例HCC患者和1193名对照个体。使用肿瘤/淋巴结/转移（TNM）系统确定临床分期，并收集各种临床指标。我们的分析显示，与对照组相比，HCC患者的 表达有统计学意义的增加，表明其在HCC进展中可能发挥作用。虽然未观察到SNP与HCC风险增加之间有实质性关联，但远处转移和血管侵犯等特定临床特征与这些SNP有显著关联，表明它们对疾病侵袭性有影响。人口统计学分析强调了饮酒和病毒性肝炎标志物等因素在HCC中的重要性。我们的研究强调了基因对HCC影响的复杂性，多态性可能影响肿瘤进展和患者预后。
