rs8103163和rs7248488基因位点的遗传变异与中国西北汉族男性喉癌相关。
Genetic Variation in the Gene at rs8103163 and rs7248488 Is Associated With Laryngeal Cancer in the Northwestern Chinese Han Male.
作者信息
Wang Shiyang, Wen Xiulin, Zhao Ruimin, Bai Yanxia
机构信息
Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Nursing, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
出版信息
Front Genet. 2022 Apr 11;13:813823. doi: 10.3389/fgene.2022.813823. eCollection 2022.
Laryngeal cancer is more common in middle-aged and older men. We conducted an association analysis between polymorphisms and laryngeal cancer (LC) risk in the Northwestern Chinese Han male. A total of 352 subjects (172 LC patients and 180 controls) were involved in this study. Agena MassARRAY was used to determine the genotypes. Unconditional logistic regression analysis was performed to explore the relevance. Two SNPs were associated with the risk of LC: rs8103163, OR = 1.41, = 0.043; rs7248488, OR = 1.45, = 0.025. Furthermore, rs8103163 was associated with an increased risk of LC under a log-additive model (OR = 1.40, = 0.042), and rs7248488 was related to a higher risk of LC under a recessive model (OR = 2.33, = 0.025) and a log-additive model (OR = 1.44, = 0.026). We first demonstrated that the rs8103163 A allele and the rs7248488 A allele in create susceptibility to laryngeal cancer in the Northwestern Chinese Han male.
喉癌在中老年男性中更为常见。我们对中国西北汉族男性的基因多态性与喉癌（LC）风险进行了关联分析。本研究共纳入352名受试者（172例LC患者和180例对照）。采用Agena MassARRAY测定基因型。进行无条件逻辑回归分析以探索相关性。有两个单核苷酸多态性（SNP）与LC风险相关：rs8103163，比值比（OR）=1.41，P=0.043；rs7248488，OR = 1.45，P = 0.025。此外，在对数加性模型下，rs8103163与LC风险增加相关（OR = 1.40，P = 0.042），在隐性模型下rs7248488与LC风险较高相关（OR = 2.33，P = 0.025），在对数加性模型下也相关（OR = 1.44，P = 0.026）。我们首次证明，在中国西北汉族男性中，rs8103163的A等位基因和rs7248488的A等位基因会增加患喉癌的易感性。
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