Inomata Silva Bianca Lumi, da Cunha Rodrigues Francisco Erivan, Tsukimata Márcio Yutaka, Botelho Bruno José Sarmento, Santos Luciana Cristina Coelho, Dos Santos Pereira Neto Gabriel, Lima Aline Cecy Rocha, André Natália Pinheiro, Galdino Sarah Marques, Monteiro Danniele Chagas, Yoshikawa Gilberto Toshimitsu, Mendonça Leonardo Teixeira, do Amaral Juliana Lasmar Ayres, de Britto Pereira Cruz Rosana, Onuma Débora Oliveira, Vallinoto Antonio Carlos Rosário, de Carvalho Klemz Bárbara Nascimento, Vallinoto Izaura Maria Vieira Cayres
Laboratório de Virologia, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Brazil.
Faculdade de Medicina, Instituto de Ciências Médica, Universidade Federal do Pará, Belém, Brazil.
Front Med (Lausanne). 2024 Aug 23;11:1419801. doi: 10.3389/fmed.2024.1419801. eCollection 2024.
Reports on the association between HTLV-2 infection and the development of diseases in the human host are rare, which has led the scientific community to believe that HTLV-2 is not an important etiological agent of lymphoproliferative or neurodegenerative disorders, which is the case for HTLV-1. In the present study, we demonstrated cases of fibromyalgia in HTLV-1 carriers and, in an unprecedented finding, in two patients with confirmed HTLV-2 infection.
A total of 957 individuals visited the Virology Laboratory at the Federal University of Pará for screening and confirmation tests for HTLV-1/2 infection. Individuals with confirmed HTLV-1 and HTLV-2 infection were clinically evaluated for signs and symptoms associated with infection.
Sixty-nine individuals (7.2%) were identified as positive for HTLV infection, with 56 confirmed cases of HTLV-1 infection (5.9%), 12 cases of HTLV-2 infection (1.2%) and one case classified as undetermined (0.1%). Sixteen (23.2%) of these patients presented with rheumatological signs and complained of diffuse pain throughout the body; 12 of whom were infected by HTLV-1 (75%) and 4 were infected by HTLV-2 (25%). After anamnesis and careful evaluation, four patients were diagnosed with fibromyalgia, two of whom were infected by HTLV-1 (16.7%; 2/12) and two by HTLV-2 (50%; 2/4). The clinical follow-up and laboratory analysis results are reported in detail in this paper.
Considering the clinical cases presented herein as the first reports of patients with HTLV-2 infection with clinical symptoms of fibromyalgia, the importance of further studies on the pathogenicity of HTLV-2, similar to what have already been performed for HTLV-1, is highlighted. Our results also confirm previous evidence of an association between HTLV-1 infection and fibromyalgia.
关于人类嗜T淋巴细胞病毒2型（HTLV-2）感染与人类宿主疾病发展之间关联的报道很少，这使得科学界认为HTLV-2不像HTLV-1那样是淋巴增殖性或神经退行性疾病的重要病原体。在本研究中，我们在HTLV-1携带者中发现了纤维肌痛病例，并且有一个前所未有的发现，即在两名确诊为HTLV-2感染的患者中也发现了纤维肌痛病例。
共有957人前往帕拉联邦大学病毒学实验室进行HTLV-1/2感染的筛查和确诊检测。对确诊为HTLV-1和HTLV-2感染的个体进行了与感染相关的体征和症状的临床评估。
69人（7.2%）被确定为HTLV感染阳性，其中56例确诊为HTLV-1感染（5.9%），12例为HTLV-2感染（1.2%），1例分类未确定（0.1%）。这些患者中有16人（23.2%）出现了风湿病体征，并主诉全身弥漫性疼痛；其中12人感染了HTLV-1（75%），4人感染了HTLV-2（25%）。经过问诊和仔细评估，4名患者被诊断为纤维肌痛，其中2人感染了HTLV-1（16.7%；2/12），2人感染了HTLV-2（50%；2/4）。本文详细报告了临床随访和实验室分析结果。
鉴于本文所呈现的临床病例是HTLV-2感染且伴有纤维肌痛临床症状患者的首例报道，凸显了进一步研究HTLV-2致病性的重要性，类似于此前针对HTLV-1所开展的研究。我们的结果也证实了先前关于HTLV-1感染与纤维肌痛之间存在关联的证据。
