• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

巴西巴伊亚州人类T细胞白血病病毒（HTLV）新的地方性感染聚集区的证据。

Evidence of New Endemic Clusters of Human T-Cell Leukemia Virus (HTLV) Infection in Bahia, Brazil.

作者信息

Pereira Felicidade Mota, de Almeida Maria da Conceição Chagas, Santos Fred Luciano Neves, Carreiro Roberto Perez, Regis-Silva Carlos Gustavo, Galvão-Castro Bernardo, Grassi Maria Fernanda Rios

机构信息

Laboratório Avançado de Saúde Pública, Fundação Oswaldo Cruz, Salvador, Brazil.

Laboratório Central de Saúde Pública Prof. Gonçalo Moniz - Secretaria da Saúde do Estado da Bahia, Salvador, Brazil.

出版信息

Front Microbiol. 2019 May 14;10:1002. doi: 10.3389/fmicb.2019.01002. eCollection 2019.

DOI:10.3389/fmicb.2019.01002
PMID:31156570
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6528468/
Abstract

BACKGROUND

Salvador, Bahia (northeastern Brazil), has been identified as the epicenter of Human T-cell leukemia virus Human T-cell leukemia virus (HTLV) type 1 infection in the country. This study aims to estimate the rate of HTLV infection and the geographical distribution of this virus in this state.

METHODS

All HTLV tests (chemiluminescence/ELISA assays/Western Blotting) performed in the Central Laboratory of Public Health of Bahia (LACEN) from 2004 to 2013 were included. Data was extracted from LACEN's database using high volume extract, transformation and load throughput. Infection rate was expressed as the number of infected individuals per 100,000 inhabitants considering municipalities grouped in microregions and/or mesoregions as the unit of analysis.

RESULTS

A total of 233,876 individuals were evaluated. Individuals were from 394 out of 417 municipalities of Bahia (94.5%). HTLV chemiluminescence/ELISA assay was found to be reactive for 3,138 individuals from whom 2,323 had WB results (1,978 positives, 62 negative and 282 indeterminate). Out of 1978 reactive samples, 1,813 (91.7%) were positive for HTLV-1, 58 (2.9%) for HTLV-2 and 107 (5.4%) were for both HTLV-1 and HTLV-2. The cumulative mean rate of HTLV-positive cases in Bahia was 14.4 per 100,000 inhabitants. Three microregions presented rates >20 HTLV-positive cases/100,000 inhabitants: Barreiras (24.83 cases per 100,000 inhabitants), Salvador (22.90 cases per 100,000 inhabitants), and Ilhéus-Itabuna (22.60 cases per 100,000 inhabitants).

CONCLUSION

HTLV infection is disseminated in the state of Bahia, with an overall moderate rate of infection. Further studies should be conducted to characterize the epidemiological and clinical profile of HTLV-infected individuals better and to propose effective prevention measures.

摘要

背景

巴西东北部的巴伊亚州萨尔瓦多市被确定为该国人类T细胞白血病病毒1型（HTLV）感染的中心。本研究旨在估计该州HTLV感染率及其病毒的地理分布。

方法

纳入2004年至2013年在巴伊亚州公共卫生中心实验室（LACEN）进行的所有HTLV检测（化学发光/酶联免疫吸附测定/蛋白质印迹法）。使用大容量提取、转换和加载吞吐量从LACEN数据库中提取数据。感染率表示为每10万居民中感染个体的数量，分析单位为按微区域和/或中区域分组的市。

结果

共评估了233,876人。这些个体来自巴伊亚州417个市中的394个（94.5%）。发现HTLV化学发光/酶联免疫吸附测定对3138人呈反应性，其中2323人有蛋白质印迹结果（1978例阳性，62例阴性，282例不确定）。在1978份反应性样本中，1813份（91.7%）HTLV-1阳性，58份（2.9%）HTLV-2阳性，107份（5.4%）HTLV-1和HTLV-2均阳性。巴伊亚州HTLV阳性病例的累积平均率为每10万居民14.4例。三个微区域的HTLV阳性病例率>20例/10万居民：巴雷拉（每10万居民24.83例）、萨尔瓦多（每10万居民22.90例）和伊列乌斯-伊塔布纳（每10万居民22.60例）。

结论

HTLV感染在巴伊亚州广泛传播，总体感染率中等。应进一步开展研究，以更好地描述HTLV感染个体的流行病学和临床特征，并提出有效的预防措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b13b/6528468/552a6dcb83d1/fmicb-10-01002-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b13b/6528468/3638a294ead9/fmicb-10-01002-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b13b/6528468/687782e5b2cd/fmicb-10-01002-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b13b/6528468/d94e14a2f693/fmicb-10-01002-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b13b/6528468/2dbdc1bfebd8/fmicb-10-01002-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b13b/6528468/f0306dbc07fa/fmicb-10-01002-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b13b/6528468/552a6dcb83d1/fmicb-10-01002-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b13b/6528468/3638a294ead9/fmicb-10-01002-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b13b/6528468/687782e5b2cd/fmicb-10-01002-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b13b/6528468/d94e14a2f693/fmicb-10-01002-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b13b/6528468/2dbdc1bfebd8/fmicb-10-01002-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b13b/6528468/f0306dbc07fa/fmicb-10-01002-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b13b/6528468/552a6dcb83d1/fmicb-10-01002-g006.jpg

相似文献

1
Evidence of New Endemic Clusters of Human T-Cell Leukemia Virus (HTLV) Infection in Bahia, Brazil.巴西巴伊亚州人类T细胞白血病病毒（HTLV）新的地方性感染聚集区的证据。
Front Microbiol. 2019 May 14;10:1002. doi: 10.3389/fmicb.2019.01002. eCollection 2019.
2
Distribution of Human T-Lymphotropic Virus (HTLV) and Hepatitis C Co-infection in Bahia, Brazil.巴西巴伊亚州人类嗜 T 淋巴细胞病毒 (HTLV) 和丙型肝炎合并感染的分布。
PLoS One. 2020 Jul 21;15(7):e0223087. doi: 10.1371/journal.pone.0223087. eCollection 2020.
3
Distribution of Human Immunodeficiency Virus and Human T-Leukemia Virus Co-infection in Bahia, Brazil.巴西巴伊亚州人类免疫缺陷病毒与人类T淋巴细胞白血病病毒合并感染情况分布
Front Med (Lausanne). 2022 Jan 10;8:788176. doi: 10.3389/fmed.2021.788176. eCollection 2021.
4
Seroprevalence and molecular epidemiology of HTLV-1 isolates from HIV-1 co-infected women in Feira de Santana, Bahia, Brazil.巴西巴伊亚州费拉德桑塔纳市HIV-1合并感染女性中HTLV-1分离株的血清阳性率及分子流行病学
AIDS Res Hum Retroviruses. 2010 Dec;26(12):1333-9. doi: 10.1089/aid.2009.0298. Epub 2010 Oct 7.
5
Line Immunoassay for Confirmation and Discrimination of Human T-Cell Lymphotropic Virus Infections in Inconclusive Western Blot Serum Samples from Brazil.用于确认和鉴别巴西不确定 Western blot 血清样本中人 T 细胞嗜淋巴细胞病毒感染的线免疫分析法。
J Clin Microbiol. 2019 Dec 23;58(1). doi: 10.1128/JCM.01384-19.
6
[HTLV-I/II infection in the state of Bahia].[巴伊亚州的人类嗜T淋巴细胞病毒I型/II型感染]
Rev Soc Bras Med Trop. 1998 Jan-Feb;31(1):35-41. doi: 10.1590/s0037-86821998000100005.
7
A new and frequent human T-cell leukemia virus indeterminate Western blot pattern: epidemiological determinants and PCR results in central African inhabitants.一种新的、频繁出现的人类 T 细胞白血病病毒不确定型 Western blot 模式：中非居民的流行病学决定因素和 PCR 结果。
J Clin Microbiol. 2012 May;50(5):1663-72. doi: 10.1128/JCM.06540-11. Epub 2012 Mar 7.
8
Performance of Commercially Available Serological Screening Tests for Human T-Cell Lymphotropic Virus Infection in Brazil.巴西市售血清学筛查试验检测人类 T 细胞嗜淋巴细胞病毒感染的性能。
J Clin Microbiol. 2018 Nov 27;56(12). doi: 10.1128/JCM.00961-18. Print 2018 Dec.
9
Phylogenetic and molecular analysis of HTLV-1 isolates from a medium sized town in northern of Brazil: tracing a common origin of the virus from the most endemic city in the country.对来自巴西北部一个中等规模城镇的人类嗜T淋巴细胞病毒1型（HTLV-1）分离株进行系统发育和分子分析：追溯该病毒在该国最流行城市的共同起源。
J Med Virol. 2008 Nov;80(11):2040-5. doi: 10.1002/jmv.21278.
10
Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this virus.巴西巴伊亚州萨尔瓦多市感染I型人类嗜T细胞病毒个体的珠蛋白单倍型表明，该病毒起源于后哥伦布时代的非洲。
J Acquir Immune Defic Syndr. 2003 Aug 1;33(4):536-42. doi: 10.1097/00126334-200308010-00016.

引用本文的文献

1
Prevalence of human T-cell leukemia virus type 1 associated inflammatory myopathies (HAIM) in Salvador, Brazil.巴西萨尔瓦多1型人类T细胞白血病病毒相关炎性肌病（HAIM）的患病率。
PLoS Negl Trop Dis. 2025 Aug 20;19(8):e0013409. doi: 10.1371/journal.pntd.0013409. eCollection 2025 Aug.
2
High Prevalence and Risk Factors for Infection with Human T-Lymphotropic Viruses 1 and 2 in the Municipality of Ananindeua, Pará, Northern Brazil.巴西北部帕拉州阿南因德乌市人类嗜T淋巴细胞病毒1型和2型感染的高流行率及危险因素
Viruses. 2025 May 28;17(6):765. doi: 10.3390/v17060765.
3
Development and validation of a multienzyme isothermal rapid amplification and lateral flow dipstick combination assay for HTLV-1 proviral DNA detection.

本文引用的文献

1
HTLV-1 is predominantly sexually transmitted in Salvador, the city with the highest HTLV-1 prevalence in Brazil.在巴西HTLV-1感染率最高的城市萨尔瓦多，HTLV-1主要通过性传播。
PLoS One. 2017 Feb 3;12(2):e0171303. doi: 10.1371/journal.pone.0171303. eCollection 2017.
2
Tuberculosis incidence in a cohort of individuals infected with human T-lymphotropic virus type 1 (HTLV-1) in Salvador, Brazil.巴西萨尔瓦多一群感染人类嗜T淋巴细胞病毒1型（HTLV-1）个体中的结核病发病率。
BMC Infect Dis. 2016 Sep 19;16:491. doi: 10.1186/s12879-016-1428-z.
3
High prevalence of bronchiectasis is linked to HTLV-1-associated inflammatory disease.
用于HTLV-1前病毒DNA检测的多酶等温快速扩增与侧向流动试纸条联合检测方法的开发与验证
J Transl Med. 2025 Jun 11;23(1):646. doi: 10.1186/s12967-025-06642-9.
4
Evaluation of QuantiFERON-TB Gold for the Diagnosis of Infection in HTLV-1-Infected Patients.用结核感染T细胞检测（QuantiFERON-TB Gold）评估人类嗜T淋巴细胞病毒1型（HTLV-1）感染患者的感染情况。
Viruses. 2024 Nov 30;16(12):1873. doi: 10.3390/v16121873.
5
HTLV infection in urban population from Mato Grosso do Sul, Central Brazil.巴西中南部马托格罗索州城市人口中的人类嗜 T 淋巴细胞病毒感染。
Retrovirology. 2024 Nov 5;21(1):18. doi: 10.1186/s12977-024-00650-1.
6
Imbalanced IL10/TGF-β production by regulatory T-lymphocytes in patients with HTLV-1-associated myelopathy/ tropical spastic paraparesis.调节性 T 淋巴细胞失衡的 IL10/TGF-β 产生与 HTLV-1 相关的脊髓病/热带痉挛性截瘫患者。
BMC Infect Dis. 2024 Jun 28;24(1):652. doi: 10.1186/s12879-024-09494-8.
7
Epidemiological and molecular evidence of intrafamilial transmission through sexual and vertical routes in Bahia, the state with the highest prevalence of HTLV-1 in Brazil.巴西 HTLV-1 感染率最高的州——巴伊亚州，通过性和垂直途径的家族内传播的流行病学和分子证据。
PLoS Negl Trop Dis. 2023 Sep 28;17(9):e0011005. doi: 10.1371/journal.pntd.0011005. eCollection 2023 Sep.
8
Impaired flexibility in patients with tropical spastic paraparesis/HTLV-associated myelopathy: evaluation via pendulum fleximeter.热带痉挛性截瘫/HTLV 相关脊髓病患者的柔韧性受损：通过摆锤式柔韧性计进行评估。
Arq Neuropsiquiatr. 2023 Mar;81(3):271-283. doi: 10.1055/s-0043-1764417. Epub 2023 Apr 14.
9
Work ability and associated factors in people living with human T-cell leukemia virus type 1.人 T 细胞白血病病毒 1 型感染者的工作能力及其相关因素。
Rev Soc Bras Med Trop. 2022 Aug 5;55:e0111. doi: 10.1590/0037-8682-0111-2022. eCollection 2022.
10
Integrative and Multidisciplinary Care for People Living With Human T-Cell Lymphotropic Virus in Bahia, Brazil: 20 Years of Experience.巴西巴伊亚州人类T细胞嗜淋巴细胞病毒感染者的综合与多学科护理：20年经验
Front Med (Lausanne). 2022 Jun 7;9:884127. doi: 10.3389/fmed.2022.884127. eCollection 2022.
支气管扩张的高患病率与人类嗜T淋巴细胞病毒1型相关炎症性疾病有关。
BMC Infect Dis. 2015 Jul 6;15:258. doi: 10.1186/s12879-015-1002-0.
4
Higher human T-lymphotropic virus type 1 subtype C proviral loads are associated with bronchiectasis in indigenous australians: results of a case-control study.高人类 T 淋巴细胞嗜性病毒 1 型 C 亚型前病毒载量与澳大利亚原住民的支气管扩张症有关：一项病例对照研究的结果。
Open Forum Infect Dis. 2014 May 28;1(1):ofu023. doi: 10.1093/ofid/ofu023. eCollection 2014 Mar.
5
Dried blood spot testing for the antenatal screening of HTLV, HIV, syphilis, toxoplasmosis and hepatitis B and C: prevalence, accuracy and operational aspects.用于HTLV、HIV、梅毒、弓形虫病以及乙型和丙型肝炎产前筛查的干血斑检测：患病率、准确性及操作方面
Braz J Infect Dis. 2014 Nov-Dec;18(6):618-24. doi: 10.1016/j.bjid.2014.05.009. Epub 2014 Jul 9.
6
HTLV-1 in pregnant women from the Southern Bahia, Brazil: a neglected condition despite the high prevalence.巴西南巴伊亚州孕妇中的 HTLV-1：尽管患病率很高，但仍被忽视。
Virol J. 2014 Feb 13;11:28. doi: 10.1186/1743-422X-11-28.
7
Epidemiological Aspects and World Distribution of HTLV-1 Infection.HTLV-1 感染的流行病学特征和世界分布。
Front Microbiol. 2012 Nov 15;3:388. doi: 10.3389/fmicb.2012.00388. eCollection 2012.
8
Keratoconjunctivitis sicca of human T cell lymphotropic virus type 1 (HTLV-1) infected individuals is associated with high levels of HTLV-1 proviral load.人类 T 细胞嗜淋巴细胞病毒 1 型（HTLV-1）感染个体的干燥性角膜结膜炎与高水平的 HTLV-1 前病毒载量有关。
J Clin Virol. 2011 Nov;52(3):177-80. doi: 10.1016/j.jcv.2011.07.016. Epub 2011 Aug 24.
9
The prevalence of human T-cell lymphotropic virus type 1 in the general population is unknown.人类 T 细胞嗜淋巴细胞病毒 1 型在普通人群中的流行情况尚不清楚。
AIDS Rev. 2009 Oct-Dec;11(4):205-14.
10
Phylogenetic and molecular analysis of HTLV-1 isolates from a medium sized town in northern of Brazil: tracing a common origin of the virus from the most endemic city in the country.对来自巴西北部一个中等规模城镇的人类嗜T淋巴细胞病毒1型（HTLV-1）分离株进行系统发育和分子分析：追溯该病毒在该国最流行城市的共同起源。
J Med Virol. 2008 Nov;80(11):2040-5. doi: 10.1002/jmv.21278.