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巴西亚马逊地区原住民中 HTLV-1 和 HTLV-2 的家族内传播：分子特征与系统发生分析。

Intrafamilial Transmission of HTLV-1 and HTLV-2 in Indigenous Peoples of the Brazilian Amazon: Molecular Characterization and Phylogenetic Analysis.

机构信息

Laboratório de Virologia, Universidade Federal do Pará, Belém 66075-110, Brazil.

Seção de Virologia, Instituto Evandro Chagas, Ananindeua 67030-000, Brazil.

出版信息

Viruses. 2024 Sep 26;16(10):1525. doi: 10.3390/v16101525.

DOI:10.3390/v16101525
PMID:39459860
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11512210/
Abstract

Human T-limphotropic virus 1 infection has a global distribution, with a high prevalence in some regions of Brazil and the world, while HTLV-2 infection is endemic mainly among indigenous people and drug users. To analyze intrafamilial transmission of HTLV-1/2 in five Kayapó indigenous peoples (Gorotire, Kararaô, Kokraimoro, Kubenkokre, and Xikrin do Bacajá), we investigated 1452 individuals who underwent serological and molecular tests. Among the 276 indigenous people with positive results, we identified intrafamily transmission in 42.7% of cases, representing 38 families. It was possible to suggest horizontal and vertical transmissions in 15.8% (6/38) and 47.4% (18/38) of the family groups, respectively. In 15.8%, it was not possible to suggest the route, which indicated that the transmission may have occurred through both vertical and horizontal routes. Through phylogenetic analyses, 35 samples positive for HTLV-2 were sequenced and classified as subtype 2c, and the two samples that tested positive for HTLV-1 were shown to belong to the cosmopolitan subtype, transcontinental subgroup (HTLV-1aA). This study confirms the intrafamilial transmission of HTLV-1/2 infection in indigenous people of the Brazilian Amazon, highlighting the importance of the sexual and mother-to-child transmission routes in maintaining the virus in these people.

摘要

人类 T 细胞嗜淋巴细胞病毒 1 型感染具有全球性分布，在巴西和世界一些地区的流行率较高，而 HTLV-2 感染主要在土著居民和吸毒者中流行。为了分析五个卡雅波原住民群体（Gorotire、Kararaô、Kokraimoro、Kubenkokre 和 Xikrin do Bacajá）中 HTLV-1/2 的家族内传播，我们对 1452 名接受血清学和分子检测的个体进行了调查。在 276 名阳性原住民中，我们发现 42.7%的病例存在家族内传播，涉及 38 个家庭。分别在 15.8%（6/38）和 47.4%（18/38）的家庭中，我们可以推测存在水平传播和垂直传播。在 15.8%的家庭中，无法推测传播途径，这表明传播可能同时通过垂直和水平途径发生。通过系统进化分析，对 35 份 HTLV-2 阳性样本进行了测序，并将其分类为 2c 亚型，而对 2 份 HTLV-1 阳性样本的分析表明它们属于世界性亚型、跨大陆亚组（HTLV-1aA）。本研究证实了巴西亚马逊地区原住民中 HTLV-1/2 感染的家族内传播，强调了性传播和母婴传播途径在维持这些人群中病毒存在的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28da/11512210/bfc4a35393fd/viruses-16-01525-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28da/11512210/d2eaaea16295/viruses-16-01525-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28da/11512210/528534ce2218/viruses-16-01525-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28da/11512210/b071cb04f04e/viruses-16-01525-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28da/11512210/06dcb60673b6/viruses-16-01525-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28da/11512210/b17ffce7432e/viruses-16-01525-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28da/11512210/6163524a5e80/viruses-16-01525-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28da/11512210/bfc4a35393fd/viruses-16-01525-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28da/11512210/d2eaaea16295/viruses-16-01525-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28da/11512210/528534ce2218/viruses-16-01525-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28da/11512210/b071cb04f04e/viruses-16-01525-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28da/11512210/06dcb60673b6/viruses-16-01525-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28da/11512210/b17ffce7432e/viruses-16-01525-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28da/11512210/6163524a5e80/viruses-16-01525-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28da/11512210/bfc4a35393fd/viruses-16-01525-g007.jpg

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