School of Biosciences and Technology, Vellore Institute of Technology, Vellore, India.
Department of Biotechnology, National Institute of Technology, Warangal, India.
Curr Drug Targets. 2024;25(13):909-918. doi: 10.2174/0113894501304751240819111831.
In recent years, mitochondria have gained significant interest in the field of biomedical research due to their impact on aging, human health, and other advanced findings in metabolic functions. The latest finding shows that metabolic interventions are a leading cause of several diseases, which has sparked interest in finding new therapeutic treatments. Apart from this, the unique inheritance of genetic material from mother to offspring can help scientists find ways to prevent mitochondrial inherited diseases. Additionally, the anti-aging benefits of controlling mitochondrial functions are also being researched. The present study aims to provide a cohesive overview of the latest findings in mitochondrial research, focusing on the role of DRP1 (Dynamin- related protein 1), a member of the GTPase family, in mediating mitochondrial fission. The first section of this paper provides a concise explanation of how DRP1 controls processes such as mitophagy and mitochondrial fission. Subsequently, the paper delves into the topic of inflammation, discussing the current findings regarding the inflammatory response mediated by DRP1. Finally, the role of mitochondrial fission mediated by DRP1 in cancer is examined, reviewing ongoing research on various types of cancer and their recurrence. Moreover, this review also covers the epigenetic regulation of mitochondrial fission. The studies were selected, and evaluated, and the information was collected to present an overview of the key findings. By exploring various aspects of research and potential links, we hope to contribute to a deeper understanding of the intricate relationship between the fields of cancer research and inflammation studies with respect to mitochondrial- based research.
近年来，由于线粒体对衰老、人类健康和代谢功能等高级发现的影响，它们在生物医学研究领域引起了极大的关注。最新的发现表明，代谢干预是多种疾病的主要原因，这引发了寻找新的治疗方法的兴趣。除此之外，从母亲遗传给后代的遗传物质的独特性可以帮助科学家找到预防线粒体遗传疾病的方法。此外，控制线粒体功能的抗衰老益处也在研究中。本研究旨在提供线粒体研究最新发现的综合概述，重点介绍 GTPase 家族成员 DRP1（Dynamin- related protein 1）在介导线粒体裂变中的作用。本文的第一部分简要解释了 DRP1 如何控制自噬和线粒体裂变等过程。随后，本文深入探讨了炎症这一主题，讨论了目前关于 DRP1 介导的炎症反应的发现。最后，研究了 DRP1 介导的线粒体裂变在癌症中的作用，综述了各种类型癌症及其复发的研究进展。此外，本综述还涵盖了线粒体裂变的表观遗传调控。选择、评估了研究，并收集了信息，以呈现主要发现的概述。通过探索研究的各个方面及其潜在联系，我们希望为深入了解癌症研究和炎症研究领域与基于线粒体的研究之间复杂关系做出贡献。
