Bianchi Porro G, Ragni G, Ruspa M, Petrillo M, Barattini G
Hepatogastroenterology. 1985 Apr;32(2):77-80.
The effect of cimetidine maintenance treatment on gonadal function has been assessed by seminal analysis plus prolactin and gonadotropin blood level concentrations. Nine patients, all with duodenal ulcer, 5 of whom had received 400 mg cimetidine at night for 18, 3 for 24 and 1 for 36 months, were studied. All patients were presumably fertile, having fathered a child born not more than 3 years before the start of cimetidine treatment. In all patients two seminal analyses were performed and blood specimens were obtained for radioimmunoassay estimation of FSH, LH and prolactin concentrations both in basal conditions and 20', 30' and 60' after the i.v. injection of Gn-RH (100 micrograms) and TRH (200 micrograms). All but one patient, in whom mild oligoasthenozoospermia was detected, had normal sperm counts and motility; moreover hormonal levels both in basal conditions and after releasing factor stimulation were found to be similar to those observed in a control group. Cimetidine maintenance treatment has no effect on sexual activity, the quality of seminal fluid or the pituitary secretion of gonadotropins or prolactin.
通过精液分析以及催乳素和促性腺激素血液水平浓度评估了西咪替丁维持治疗对性腺功能的影响。研究对象为9名十二指肠溃疡患者，其中5人每晚服用400毫克西咪替丁，服用时间分别为18个月、3人服用24个月、1人服用36个月。所有患者据推测均有生育能力，在开始西咪替丁治疗前3年内均育有子女。对所有患者进行了两次精液分析，并采集血样用于放射免疫分析，以测定基础状态下以及静脉注射促性腺激素释放激素（Gn-RH，100微克）和促甲状腺激素释放激素（TRH，200微克）后20分钟、30分钟和60分钟时的促卵泡激素（FSH）、促黄体生成素（LH）和催乳素浓度。除1例患者检测出轻度少弱精子症外，所有患者的精子计数和活力均正常；此外，基础状态下以及释放因子刺激后的激素水平与对照组观察到的水平相似。西咪替丁维持治疗对性功能、精液质量或垂体促性腺激素或催乳素的分泌没有影响。
