Just H M, Reiber T, Bassler M, Daschner F D
Immun Infekt. 1985 May;13(3):119-23.
The in vitro activity of piperacillin at 1/4, 1 and 4 X MHK against 5 strains each of Pseudomonas aeruginosa, Escherichia coli and Streptococcus faecalis was compared in Mueller-Hinton-bouillon and human serum. Serum without piperacillin was bacteriostatic against P. aeruginosa for 8 hrs., against E. coli for 24 hrs. Subinhibitory piperacillin concentrations were bacteriostatic against E. coli, but had no effect against P. aeruginosa and S. faecalis. Bactericidal activity against E. coli was achieved at 1 X MHK against P. aeruginosa and S. faecalis at 4 X MHK. Except for P. aeruginosa in concentrations of 1/4 and 1 X MHK the piperacillin activity in bouillon and serum was almost identical.
在穆勒-欣顿肉汤和人血清中，比较了哌拉西林在1/4、1和4倍最小抑菌浓度（MHK）时对5株铜绿假单胞菌、5株大肠埃希菌和5株粪肠球菌的体外活性。不含哌拉西林的血清对铜绿假单胞菌的抑菌作用可持续8小时，对大肠埃希菌可持续24小时。亚抑菌浓度的哌拉西林对大肠埃希菌有抑菌作用，但对铜绿假单胞菌和粪肠球菌无作用。对大肠埃希菌的杀菌活性在1倍MHK时达到，对铜绿假单胞菌和粪肠球菌在4倍MHK时达到。除了1/4和1倍MHK浓度的铜绿假单胞菌外，哌拉西林在肉汤和血清中的活性几乎相同。
