Daschner F D, Bassler M, Grundau D, Dieterle L, Just H M
Immun Infekt. 1983 Nov;11(6):221-8.
The bactericidal activity of ceftazidime against 5 serum resistant Staphylococcus epidermidis and 5 serum sensitive Pseudomonas aeruginosa strains was compared in Mueller-Hinton broth and normal human serum. Except for the first 4 hours incubation time ceftazidime was less active in serum as compared to broth against the serum resistant staphylococci at subinhibitory concentrations. Against the serum sensitive Pseudomonas aeruginosa strains the in vitro activity of ceftazidime in serum was significantly higher than in broth at all concentrations investigated. In vitro activity of ceftazidime was best in combination with leukocytes and serum against a Staphylococcus aureus and a Pseudomonas aeruginosa strain. Leukocytes in serum enhanced the bactericidal activity of ceftazidime against a Pseudomonas aeruginosa strain already at 1/4 MIC, which could only slightly be improved at 1 MIC, but not at 4 MIC.
在穆勒-欣顿肉汤和正常人血清中比较了头孢他啶对5株血清耐药表皮葡萄球菌和5株血清敏感铜绿假单胞菌的杀菌活性。除了最初4小时的孵育时间外，在亚抑菌浓度下，与肉汤相比，头孢他啶在血清中对血清耐药葡萄球菌的活性较低。在所有研究浓度下，对于血清敏感的铜绿假单胞菌菌株，头孢他啶在血清中的体外活性显著高于在肉汤中的活性。头孢他啶与白细胞和血清联合使用时，对金黄色葡萄球菌和铜绿假单胞菌菌株的体外活性最佳。血清中的白细胞在头孢他啶浓度仅为1/4 MIC时就增强了其对铜绿假单胞菌菌株的杀菌活性，在1 MIC时杀菌活性仅略有提高，但在4 MIC时没有提高。
