Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Nordic Institute of Dental Materials (NIOM AS), Oslo, Norway.
Acta Odontol Scand. 2024 Sep 9;83:453-460. doi: 10.2340/aos.v83.41193.
Purpose of this research was to examine the onset, progression and wear rates of dental erosion in an established mouse model.
Dental erosion in mice was experimentally induced, and the acidic effects of cola drink on their teeth after 2, 4 and 6-weeks were closely analysed by scanning electron microscopy. The tooth height and enamel or dentin loss were established. Results: The dental erosion on the molars showed clear progression from 2 to 6 weeks. By the 2-week mark, a significant portion of enamel was already eroded, revealing the dentin on the lingual cusps. When adjusted for attritional wear, molars exposed to cola for 2 weeks showed a 35% drop in lingual tooth height compared to controls (533 μm vs. 818 μm). At 4 and 6 weeks, the cola-exposed group continued to display decreased lingual tooth heights by 40% (476 μm vs. 799 μm) and 43% (440 μm vs. 767 μm), respectively.
This study revealed significant acidic effects of cola drink on mouse molars as early as 2 weeks. These findings highlight the challenge of monitoring dental erosion clinically and underscore the importance of early preventive and intervention measures.
本研究旨在观察已建立的小鼠模型中牙酸蚀的起始、进展和磨损率。
通过扫描电子显微镜对实验诱导的小鼠牙酸蚀以及可乐饮料在 2、4 和 6 周后对其牙齿的酸性影响进行了密切分析。测量了牙齿高度和牙釉质或牙本质的损失。结果：磨牙上的牙酸蚀从 2 周到 6 周呈现明显的进展。在 2 周时，已经有很大一部分牙釉质被侵蚀，舌侧牙尖暴露出牙本质。与对照组相比（533μm 对 818μm），暴露于可乐中的磨牙在经过磨耗性磨损校正后，其 2 周时的舌侧牙齿高度下降了 35%。在 4 周和 6 周时，可乐暴露组的舌侧牙齿高度继续分别下降了 40%（476μm 对 799μm）和 43%（440μm 对 767μm）。结论：本研究早在 2 周时就揭示了可乐饮料对小鼠磨牙的显著酸性影响。这些发现突出了临床监测牙酸蚀的挑战，并强调了早期预防和干预措施的重要性。
