Department of Pediatric Dentistry and Orthodontics, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Department of Restorative Dentistry, University of São Paulo School of Dentistry, Cidade Universitária, São Paulo, Brazil.
Oral Dis. 2018 Apr;24(3):355-362. doi: 10.1111/odi.12740. Epub 2017 Sep 25.
To investigate the susceptibility of partially desalivated rats to erosive tooth wear (ETW); the anti-erosive effect of a calcium-supplemented beverage; and the quantification of ETW by microcomputed tomography (micro-CT).
The study population consisted of thirty-eight rats, divided into partially desalivated (n = 19) and normal salivary flow (n = 19). They were randomly allocated into three subgroups (n = 6-7): A-diet soda, B-diet soda + calcium, C-water (control). Solutions were provided ad libitum for 28 days, and the rats were euthanized afterwards. Each left hemi-mandible was scanned using micro-CT for enamel volume (three molars) calculation. Visual analysis of photographs of the lingual surface of first molars was performed independently by three blinded examiners. Data were statistically analysed (α = .05).
Micro-CT revealed no significant differences between partially desalivated or normal groups. Rats consuming A had more enamel loss than those consuming B or C, which did not differ from each other. For visual analysis, desalivation did not affect ETW. Rats consuming C showed the lowest ETW, followed by B and then A, for both partially desalivated and normal rats. Spearman correlation between the two ETW quantification methods was -.65.
Partial desalivation did not increase ETW. Ca-containing beverage prevented ETW. Micro-CT quantified ETW, although it was not as sensitive as visual analysis.
研究部分去唾液大鼠对侵蚀性牙磨损（ETW）的易感性；钙补充饮料的抗侵蚀作用；以及微计算机断层扫描（micro-CT）对 ETW 的定量。
研究人群包括 38 只大鼠，分为部分去唾液（n=19）和正常唾液流（n=19）。它们被随机分为三组（n=6-7）：A-苏打水，B-苏打水+钙，C-水（对照）。28 天后自由提供溶液，然后处死大鼠。使用 micro-CT 对每只左侧半下颌进行扫描，以计算牙釉质体积（三个磨牙）。第一磨牙舌面照片的视觉分析由三名盲法检查者独立进行。数据进行了统计学分析（α=0.05）。
micro-CT 显示部分去唾液或正常组之间没有显著差异。饮用 A 的大鼠比饮用 B 或 C 的大鼠牙釉质损失更多，而 B 和 C 之间没有差异。对于视觉分析，去唾液作用不会影响 ETW。与 B 和 A 相比，饮用 C 的大鼠表现出最低的 ETW，无论是部分去唾液还是正常大鼠。两种 ETW 定量方法之间的 Spearman 相关性为-.65。
部分去唾液作用不会增加 ETW。含钙饮料可预防 ETW。micro-CT 定量 ETW，尽管不如视觉分析敏感。
