淋病奈瑟菌分离株对氟喹诺酮类抗菌药物的鉴别

Differentiation of fluorinated quinolone antibacterials with Neisseria gonorrhoeae isolates.

作者信息

Rohlfing S R, Landmesser J E, Gerster J F, Pecore S E, Stern R M

出版信息

J Antimicrob Chemother. 1985 May;15(5):539-44. doi: 10.1093/jac/15.5.539.

DOI:10.1093/jac/15.5.539

Abstract

Clinical isolates of Neisseria gonorrhoeae were tested for growth inhibition by various quinolones. One acrosoxacin-resistant isolate was also resistant to several fluorinated quinolones with 7-heterocyclic substitution, but, inhibitory concentrations were not elevated for quinolones substituted with a methyl group in the corresponding position (nalidixic acid:position 7, S-25930:position 8) or unsubstituted (flumequine:position 8). Isolates resistant to flumequine demonstrated elevated inhibitory concentrations for all quinolones examined.

摘要

对淋病奈瑟菌的临床分离株进行了各种喹诺酮类药物的生长抑制测试。一株对阿克罗沙星耐药的分离株也对几种具有7-杂环取代的氟化喹诺酮类药物耐药，但对于在相应位置被甲基取代（萘啶酸：7位，S-25930：8位）或未被取代（氟甲喹：8位）的喹诺酮类药物，其抑制浓度并未升高。对氟甲喹耐药的分离株对所有检测的喹诺酮类药物均表现出升高的抑制浓度。