Bergin C J, Phillips P, Chan R M, Ruedy J, Crichton E P
J Antimicrob Chemother. 1985 May;15(5):613-21. doi: 10.1093/jac/15.5.613.
The effectiveness and safety of parenterally administered ceftazidime were assessed in 20 patients with infections caused by Pseudomonas aeruginosa or Serratia marcescens. There were six infections involving the urinary tract, six wound infections, one respiratory tract infection, three septicaemias, one empyema, one mastoiditis and two infections of the epididymis. Sixteen of the isolates were resistant to at least one aminoglycoside antibiotic. Fifteen patients were clinically and bacteriologically cured, two patients improved, but had relapses and three patients showed no response. The lack of clinical response was due to the development of resistance by P. aeruginosa in two patients with osteomyelitis, one of whom also had diabetes mellitus. The third patient who had chronic lymphocytic leukaemia developed post-operative osteomyelitis and septicaemia with serratia. She did not respond to treatment. Side effects consisted of a positive direct Coomb's test without evidence of haemolysis in two patients and a mild maculopapular rash in one patient.
对20例由铜绿假单胞菌或粘质沙雷氏菌引起感染的患者，评估了胃肠外给药头孢他啶的有效性和安全性。有6例尿路感染、6例伤口感染、1例呼吸道感染、3例败血症、1例脓胸、1例乳突炎和2例附睾炎感染。分离出的菌株中有16株对至少一种氨基糖苷类抗生素耐药。15例患者临床和细菌学治愈，2例患者病情改善但复发，3例患者无反应。缺乏临床反应是由于2例骨髓炎患者的铜绿假单胞菌产生了耐药性，其中1例还患有糖尿病。第三位患有慢性淋巴细胞白血病的患者术后发生了粘质沙雷氏菌骨髓炎和败血症。她对治疗无反应。副作用包括2例患者直接抗人球蛋白试验阳性但无溶血证据，1例患者出现轻度斑丘疹。
