Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Sci Rep. 2024 Sep 9;14(1):20988. doi: 10.1038/s41598-024-71674-y.
Image segmentation of the liver is an important step in treatment planning for liver cancer. However, manual segmentation at a large scale is not practical, leading to increasing reliance on deep learning models to automatically segment the liver. This manuscript develops a generalizable deep learning model to segment the liver on T1-weighted MR images. In particular, three distinct deep learning architectures (nnUNet, PocketNet, Swin UNETR) were considered using data gathered from six geographically different institutions. A total of 819 T1-weighted MR images were gathered from both public and internal sources. Our experiments compared each architecture's testing performance when trained both intra-institutionally and inter-institutionally. Models trained using nnUNet and its PocketNet variant achieved mean Dice-Sorensen similarity coefficients>0.9 on both intra- and inter-institutional test set data. The performance of these models suggests that nnUNet and PocketNet liver segmentation models trained on a large and diverse collection of T1-weighted MR images would on average achieve good intra-institutional segmentation performance.
肝脏的图像分割是肝癌治疗计划的重要步骤。然而,大规模的手动分割是不切实际的,因此越来越依赖深度学习模型来自动分割肝脏。本手稿开发了一种可推广的深度学习模型,用于在 T1 加权磁共振图像上分割肝脏。特别是,使用来自六个地理位置不同的机构收集的数据,考虑了三种不同的深度学习架构(nnUNet、PocketNet、Swin UNETR)。总共从公共和内部来源收集了 819 张 T1 加权磁共振图像。我们的实验比较了在内部和机构间训练时每个架构的测试性能。在内部和机构间测试集数据上,使用 nnUNet 及其 PocketNet 变体训练的模型的平均 Dice-Sorensen 相似系数均>0.9。这些模型的性能表明,在大量多样化的 T1 加权磁共振图像上训练的 nnUNet 和 PocketNet 肝脏分割模型平均可以实现良好的内部分割性能。