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血清脂质组与创伤性脑损伤患者的神经影像学特征相关。

Serum lipidome associates with neuroimaging features in patients with traumatic brain injury.

作者信息

Thomas Ilias, Newcombe Virginia F J, Dickens Alex M, Richter Sophie, Posti Jussi P, Maas Andrew I R, Tenovuo Olli, Hyötyläinen Tuulia, Büki András, Menon David K, Orešič Matej

机构信息

School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

School of Information and Engineering, Dalarna University, 79131 Falun, Sweden.

出版信息

iScience. 2024 Aug 3;27(9):110654. doi: 10.1016/j.isci.2024.110654. eCollection 2024 Sep 20.

DOI:10.1016/j.isci.2024.110654
PMID:39252979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11381842/
Abstract

Acute traumatic brain injury (TBI) is associated with substantial abnormalities in lipid biology, including changes in the structural lipids that are present in the myelin in the brain. We investigated the relationship between traumatic microstructural changes in white matter from magnetic resonance imaging (MRI) and quantitative lipidomic changes from blood serum. The study cohort included 103 patients from the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study. Diffusion tensor fitting generated fractional anisotropy (FA) and mean diffusivity (MD) maps for the MRI scans while ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry was applied to analyze the lipidome. Increasing severity of TBI was associated with higher MD and lower FA values, which scaled with different lipidomic signatures. There appears to be consistent patterns of lipid changes associating with the specific microstructure changes in the CNS white matter, but also regional specificity, suggesting that blood-based lipidomics may provide an insight into the underlying pathophysiology of TBI.

摘要

急性创伤性脑损伤（TBI）与脂质生物学的显著异常有关，包括大脑髓鞘中存在的结构脂质的变化。我们研究了磁共振成像（MRI）中白质创伤性微观结构变化与血清定量脂质组学变化之间的关系。研究队列包括来自欧洲创伤性脑损伤协作有效性研究（CENTER-TBI）的103名患者。扩散张量拟合为MRI扫描生成了分数各向异性（FA）和平均扩散率（MD）图，同时应用超高效液相色谱四极杆飞行时间质谱分析脂质组。TBI严重程度的增加与更高的MD值和更低的FA值相关，这些值与不同的脂质组学特征相关。似乎存在与中枢神经系统白质特定微观结构变化相关的脂质变化的一致模式，但也存在区域特异性，这表明基于血液的脂质组学可能为TBI的潜在病理生理学提供见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/11381842/25b0d300b20d/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/11381842/3c12d0c2f438/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/11381842/cc8a37aa48c8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/11381842/69e36d59b159/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/11381842/14fcef191741/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/11381842/9b72f05115d3/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/11381842/25b0d300b20d/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/11381842/3c12d0c2f438/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/11381842/cc8a37aa48c8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/11381842/69e36d59b159/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/11381842/14fcef191741/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/11381842/9b72f05115d3/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ad7/11381842/25b0d300b20d/gr5.jpg

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