Reyes Martin, Smith Sage, Lam Kelly, Adel Yasaman, Patel Nimesh B, Sayah Diane N
University of Houston, College of Optometry, Houston, Texas.
Ophthalmol Sci. 2025 Apr 26;5(5):100814. doi: 10.1016/j.xops.2025.100814. eCollection 2025 Sep-Oct.
Measuring ocular rigidity (OR) and the pulsatile choroidal volume change (ΔV) from childhood to adulthood would provide essential insight into the role of the sclera and choroid in axial myopia. A validated measurement method based on Beaton et al (2015) is the only noninvasive, direct, and reliable method available, yet it has never been used in children. This study aims to assess the feasibility and repeatability of noninvasive OR and ΔV measurements in children and young adults using this method.
This is a cross-sectional study.
Children and young adults aged 6 to 26 years.
OCT videos were acquired using enhanced depth imaging mode. A neural network (NN) approach was used to extract the choroid segmentation from OCT videos, which was then used to measure choroidal filling as described by Beaton et al. Ocular rigidity was computed from the ΔV and the ocular pulse amplitude using Friedenwald equation. Intrasession repeatability was assessed for subjects with 2 consecutive measurements of OR.
Ocular rigidity, pulsatile choroidal volume change, and the method's yield.
Sixty-seven subjects (67 eyes, 27 males) aged 13 ± 6 years were enrolled, and 62 subjects completed the study. ΔV and OR were computed. Out of the 62 videos, 98% (61) of the OCT videos were successfully segmented using the NN approach, with heart rate detectable in 79% (48) of the videos. Average OR and ΔV were 0.027 ± 0.022 μL and 5.7 ± 2.8 μL, respectively (n = 48). The mean submacular choroidal thickness (CT) and pulsatile CT change were 283.6 ± 40.4 μm and 8.36 ± 4.4 μm, respectively. Intrasession repeatability for OR and ΔV was assessed in 31 eyes and was determined to be excellent based on a single measure intraclass correlation coefficient of 0.912, 95% confidence interval (CI) (0.825, 0.956) and 0.941, 95% CI (0.879, 0.972), respectively and a within-subject standard deviation of 0.0037 μL and 1.14 μL, respectively.
Measures of OR and ΔV are achievable in children and young adults and have good repeatability. This noninvasive method can be used to establish structural biomechanical changes of the sclera and choroid with myopic axial elongation in childhood and beyond.
The author(s) have no proprietary or commercial interest in any materials discussed in this article.
测量从儿童期到成年期的眼硬度（OR）和搏动性脉络膜体积变化（ΔV），将为巩膜和脉络膜在轴性近视中的作用提供重要见解。基于比顿等人（2015年）的一种经过验证的测量方法是唯一可用的非侵入性、直接且可靠的方法，但从未在儿童中使用过。本研究旨在评估使用该方法对儿童和年轻人进行非侵入性OR和ΔV测量的可行性和可重复性。
这是一项横断面研究。
6至26岁的儿童和年轻人。
使用增强深度成像模式获取光学相干断层扫描（OCT）视频。采用神经网络（NN）方法从OCT视频中提取脉络膜分割，然后按照比顿等人所述用于测量脉络膜充盈。使用弗里登瓦尔德方程根据ΔV和眼脉搏幅度计算眼硬度。对连续进行2次OR测量的受试者评估测量期间的可重复性。
眼硬度、搏动性脉络膜体积变化以及该方法的成功率。
纳入了67名年龄为13±6岁的受试者（67只眼，27名男性），62名受试者完成了研究。计算了ΔV和OR。在62个视频中，98%（61个）的OCT视频使用NN方法成功分割，79%（48个）的视频可检测到心率。平均OR和ΔV分别为0.027±0.022微升和5.7±2.8微升（n = 48）。平均黄斑下脉络膜厚度（CT）和搏动性CT变化分别为283.6±40.4微米和8.36±4.4微米。在31只眼中评估了OR和ΔV测量期间的可重复性，基于单测量组内相关系数分别为0.912、95%置信区间（CI）（0.825，0.956）和0.941、95%CI（0.879，0.972），以及受试者内标准差分别为0.0037微升和1.14微升，确定可重复性极佳。
儿童和年轻人可以实现OR和ΔV测量，且具有良好的可重复性。这种非侵入性方法可用于确定儿童期及以后巩膜和脉络膜随近视性眼轴伸长的结构生物力学变化。
作者对本文讨论的任何材料均无所有权或商业利益。
