Department of Internal Medicine III: Cardiology, Angiology & Pulmonology, Cardio-Oncology Unit, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 69120, Heidelberg, Germany.
Curr Heart Fail Rep. 2024 Dec;21(6):505-514. doi: 10.1007/s11897-024-00681-x. Epub 2024 Sep 10.
Elevated troponin levels are well established e.g., for the diagnosis of suspected acute coronary syndrome in symptomatic patients. In contrast, troponin elevations in asymptomatic cancer patients emerge as a complex phenomenon, challenging traditional perceptions of its association solely with cardiac events.
Recent data support the predictive value of cardiac biomarker for all-cause mortality and cardiotoxicity in cancer patients. This review gives an overview about the current literature about cardiac troponins in prediction and identification of high-risk cancer patients. The overview is focusing on diagnostic challenges, biomarker significance, and gaps of knowledge. Latest publications highlight the relevance of cardiac troponin in risk analysis before cancer treatment as well as a potential diagnostic gatekeeper for further cardiological diagnostics and therapy.
肌钙蛋白水平升高已得到充分证实，例如，用于诊断有症状的疑似急性冠状动脉综合征患者。相比之下，无症状癌症患者的肌钙蛋白升高是一种复杂现象，挑战了其与心脏事件相关的传统观念。
最近的数据支持心脏生物标志物对癌症患者全因死亡率和心脏毒性的预测价值。这篇综述概述了目前关于心脏肌钙蛋白在预测和识别高危癌症患者方面的文献。该综述侧重于诊断挑战、生物标志物意义和知识空白。最新出版物强调了心脏肌钙蛋白在癌症治疗前风险分析中的相关性，以及进一步进行心脏病学诊断和治疗的潜在诊断网关。
