Department of Nephrology, Shanghai Kidney Development and Pediatric Kidney Disease Research Center, Children's Hospital of Fudan University, Shanghai, 201102, China.
Department of Neonatology, Children's Hospital of Fudan University, Shanghai, 201102, China.
Sci Rep. 2024 Sep 10;14(1):21076. doi: 10.1038/s41598-024-72215-3.
The association between tobacco smoke exposure and sleep has been widely discussed, but the correlation between serum cotinine levels and sleep health outcomes in adolescents has not been well described. This study aimed to further evaluate the association between serum cotinine levels and sleep health outcomes in adolescents using data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. This cross-sectional study included participants aged 16-19 years from the NHANES 2005-2018. A weighted multivariate logistic regression model was used for the primary analysis. A restricted cubic spline (RCS) model was employed to investigate the non-linear association between serum cotinine levels and trouble sleeping. Subgroup analyses based on population characteristics were also conducted. In total, 2630 participants were included, which are representative of the 11.5 million US adolescents. Higher serum cotinine levels (≥ 3 ng/ml) were significantly associated with trouble sleeping in the fully adjusted model (odds ratio [OR] 1.817). The RCS model revealed a non-linear relationship between serum cotinine levels and trouble sleeping. Subgroup analyses indicated that this relationship was consistent and stable across various population characteristics. Serum cotinine levels are associated with sleep health outcomes in adolescents, with high serum cotinine levels being linked to increased trouble sleeping and longer or shorter sleep duration.
吸烟与睡眠之间的关系已被广泛讨论，但血清可替宁水平与青少年睡眠健康结果之间的相关性尚未得到很好的描述。本研究旨在利用 2005 年至 2018 年国家健康和营养检查调查（NHANES）的数据，进一步评估血清可替宁水平与青少年睡眠健康结果之间的关系。本横断面研究纳入了 NHANES 2005-2018 中年龄在 16-19 岁的参与者。主要分析采用加权多变量逻辑回归模型。采用受限立方样条（RCS）模型来研究血清可替宁水平与睡眠问题之间的非线性关联。还根据人口特征进行了亚组分析。共纳入 2630 名参与者，代表了 1150 万美国青少年。在完全调整模型中，较高的血清可替宁水平（≥3ng/ml）与睡眠问题显著相关（比值比[OR]1.817）。RCS 模型显示血清可替宁水平与睡眠问题之间存在非线性关系。亚组分析表明，这种关系在各种人口特征中是一致和稳定的。血清可替宁水平与青少年的睡眠健康结果有关，较高的血清可替宁水平与睡眠问题增加以及睡眠时间较长或较短有关。
