Department of Thyroid and Breast Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, China.
Sci Rep. 2024 Jul 9;14(1):15781. doi: 10.1038/s41598-024-66937-7.
Tobacco smoke exposure has been demonstrated to impede bone remodeling and diminish bone density, yet research regarding its correlation with parathyroid hormone (PTH) remains limited. This study aims to investigate the relationship between tobacco smoke exposure and serum PTH levels in adults aged 20 years and older. This study included 7,641 participants from two cycles of the National Health and Nutrition Examination Survey (NHANES, United States, 2003- 2006). Reflect tobacco smoke exposure through serum cotinine levels, and use an adjusted weighted multivariate linear regression model to test the independent linear relationship between serum cotinine and PTH. Stratified analysis was conducted to validate the sensitivity of the conclusions. Smooth curve fitting and threshold effect analysis were performed to assess the non-linear relationship. After comprehensive adjustment using weighted multivariate regression analysis, a negative correlation was found between serum cotinine and PTH levels. The interaction p-values in subgroup analyses were all greater than 0.05. Moreover, smooth curve fitting indicated a non-linear relationship between serum cotinine and PTH, with a turning point observed. Our research indicates that tobacco smoke exposure is negatively correlated and independent of serum parathyroid hormone levels, indicating that long-term tobacco smoke exposure may lead to parathyroid dysfunction in adults.
烟草烟雾暴露已被证实会阻碍骨重建并降低骨密度，但关于其与甲状旁腺激素（PTH）相关性的研究仍然有限。本研究旨在调查 20 岁及以上成年人中烟草烟雾暴露与血清甲状旁腺激素水平之间的关系。本研究纳入了来自美国国家健康和营养检查调查（NHANES）两个周期（2003-2006 年）的 7641 名参与者。通过血清可替宁水平反映烟草烟雾暴露，并使用调整后的加权多元线性回归模型来检验血清可替宁与 PTH 之间的独立线性关系。进行分层分析以验证结论的敏感性。进行平滑曲线拟合和阈值效应分析以评估非线性关系。经过加权多元回归分析的综合调整后，发现血清可替宁与 PTH 水平之间存在负相关。亚组分析中的交互 p 值均大于 0.05。此外，平滑曲线拟合表明血清可替宁与 PTH 之间存在非线性关系，并观察到转折点。我们的研究表明，烟草烟雾暴露与血清甲状旁腺激素水平呈负相关且独立，这表明长期烟草烟雾暴露可能导致成年人甲状旁腺功能障碍。
