Department of Clinical Science, Intervention, and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Södra Grev Rosengatan 30, 70362, Örebro, Sweden.
Sci Rep. 2024 Sep 10;14(1):21143. doi: 10.1038/s41598-024-72390-3.
Peyronie's disease (PD) has detrimental effects on the quality of life, mental health, sexual functioning and several other aspects that increase the risk of relationship problems. However, no study to date has assessed the risk of relationship separation in med with PD. Herein, we utilized data from Swedish national registers to examine the risk of relationship separation in men with PD. We conducted a matched cohort study on men born 1933-1992, followed from 1997 to 2013. PD was defined as a physician-assigned diagnosis according to the International Classification of Diseases, Tenth version. Each man with PD (n = 8020) was matched with 10 comparison men. We defined relationship separation as (1) ever separated, and (2) separation rate. We used log-linear regression to estimate the risk ratio, and rate ratio of relationship separation. We adjusted for matching variables (birth year and country of birth), and an indicator of each follow-up year. We found that men with PD had a 13% increased risk of relationship separation (risk ratio 1.13, 95% confidence interval [CI] 1.08-1.17). The rate of relationship separation events, measured on a yearly basis, was increased by 18% (rate ratio 1.18, CI 1.12-1.24), and remained similar when adjusting for follow-up year and socio-economic status.
佩罗尼氏病（PD）对生活质量、心理健康、性功能和其他几个方面都有不利影响，这些都会增加人际关系问题的风险。然而，迄今为止，尚无研究评估 PD 患者的人际关系分离风险。在此，我们利用瑞典国家登记处的数据，来研究 PD 患者的人际关系分离风险。我们对出生于 1933 年至 1992 年的男性进行了匹配队列研究，随访时间从 1997 年到 2013 年。PD 根据国际疾病分类，第十版，由医生诊断。每个患有 PD 的男性（n=8020）都与 10 名对照男性匹配。我们将人际关系分离定义为（1）曾经分离，以及（2）分离率。我们使用对数线性回归来估计风险比和分离率的风险比。我们调整了匹配变量（出生年份和出生地）和每个随访年份的指标。我们发现，患有 PD 的男性发生人际关系分离的风险增加了 13%（风险比 1.13，95%置信区间[CI]1.08-1.17）。每年衡量的人际关系分离事件的发生率增加了 18%（比率比 1.18，CI 1.12-1.24），并且在调整随访年份和社会经济地位后仍然相似。
