Lanzhou University Second Hospital, Lanzhou University, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou 730030, Gansu, China.
School of Stomatology, Lanzhou University, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou 730000, Gansu, China.
J Mater Chem B. 2024 Oct 9;12(39):9835-9844. doi: 10.1039/d4tb00604f.
Epigallocatechin-3-gallate (EGCG) is the most effective active ingredient in tea polyphenols and belongs to the category of catechins. EGCG has excellent antioxidant activity, anti-inflammatory, osteogenesis-promoting, and antibacterial properties, and has been widely studied in orthopedic diseases such as osteoporosis. To reach the lesion site, achieve sustained release, promote osteogenesis, regulate macrophage polarization, and improve the physical properties of materials, EGCG needs to be cross-linked or incorporated in bone regeneration materials. This article reviews the application of bone regeneration materials combined with EGCG, including natural polymer bone regeneration materials, synthetic polymer bone regeneration materials, bioceramic bone regeneration materials, metal bone regeneration materials, hydrogel bone regeneration materials and metal-EGCG networks. In addition, the fabrication methods for the regenerated scaffolds are also elaborated in the text. To sum up, it reveals the excellent development potential of materials containing EGCG and the shortcomings of current research, which will provide important reference for the future exploration of bone regeneration materials containing EGCG.
没食子酸表没食子儿茶素酯（EGCG）是茶多酚中最有效的活性成分，属于儿茶素类。EGCG 具有优异的抗氧化、抗炎、促骨生成和抗菌特性，在骨质疏松等骨科疾病方面得到了广泛研究。为了到达病变部位、实现持续释放、促进成骨、调节巨噬细胞极化和改善材料的物理性能，EGCG 需要交联或结合到骨再生材料中。本文综述了与 EGCG 结合的骨再生材料的应用，包括天然聚合物骨再生材料、合成聚合物骨再生材料、生物陶瓷骨再生材料、金属骨再生材料、水凝胶骨再生材料和金属-EGCG 网络。此外，文中还阐述了再生支架的制备方法。总之，揭示了含 EGCG 的材料具有优异的发展潜力和当前研究的不足，为未来含 EGCG 的骨再生材料的探索提供了重要参考。
