Department of Oral Implantology, West China Hospital of Stomatology; State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan, China.
Stomatology College & the Affiliated Stomatology Hospital of Southwest Medical University, Luzhou, Sichuan, China.
J Biomed Mater Res A. 2020 Dec;108(12):2395-2408. doi: 10.1002/jbm.a.36991. Epub 2020 Jul 9.
Because of excellent biocompatibility, antioxidant activity, and anti-caries ability, epigallocatechin-3-gallate (EGCG) has been widely studied in the treatment of oral diseases, such as periodontal disease, oral cancer, and dental caries. To reach the site of the lesion or achieve sustained release, play the role of anti-caries, anti-inflammatory, or to maintain or improve the physical properties of the modified material，EGCG need to be cross-linked or embedded with dental adhesives, barrier membranes, bone replacement materials, tissue regeneration materials, and antimicrobial anti-caries materials to better prevent or treat oral diseases. This article reviews the applications of EGCG in oral materials, involving various areas of the oral cavity, reveals their excellent potential, and sees shortcomings in these research to promote the better development of EGCG applications in oral materials such as oral repair materials, bone tissue engineering materials and antibacterial and anti-caries materials.
由于具有出色的生物相容性、抗氧化活性和抗龋能力，表没食子儿茶素没食子酸酯（EGCG）已被广泛研究用于治疗口腔疾病，如牙周病、口腔癌和龋齿。为了到达病变部位或实现持续释放，发挥抗龋、抗炎作用，或维持或改善改性材料的物理性能，需要将 EGCG 与牙用黏结剂、屏障膜、骨替代材料、组织再生材料和抗菌抗龋材料交联或嵌入，以更好地预防或治疗口腔疾病。本文综述了 EGCG 在口腔材料中的应用，涉及口腔的各个领域，揭示了其优异的潜力，并看到了这些研究中的不足之处，以促进 EGCG 在口腔修复材料、骨组织工程材料和抗菌抗龋材料等口腔材料中的应用得到更好的发展。
