Tianjin Key Laboratory of Brain Science and Neuroengineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China.
Key Laboratory of Protein and Peptide Drugs, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Nanoscale. 2024 Oct 17;16(40):18644-18665. doi: 10.1039/d4nr02883j.
Designing biomimetic materials with high activity and customized biological functions by mimicking the central structure of biomolecules has become an important avenue for the development of medical materials. As an essential electron carrier, the iron-sulfur (Fe-S) clusters have the advantages of simple structure and high electron transport capacity. To rationally design and accurately construct functional materials, it is crucial to clarify the electronic structure and conformational relationships of Fe-S clusters. However, due to the complex catalytic mechanism and synthetic process , it is hard to reveal the structure-activity relationship of Fe-S clusters accurately. This review introduces the main structural types of Fe-S clusters and their catalytic mechanisms first. Then, several typical structural design strategies of biomimetic Fe-S clusters are systematically introduced. Furthermore, the development of Fe-S clusters in the biocatalytic field is enumerated, including tumor treatment, antibacterial, virus inhibition and plant photoprotection. Finally, the problems and development directions of Fe-S clusters are summarized. This review aims to guide people to accurately understand and regulate the electronic structure of Fe-S at the atomic level, which is of great significance for designing biomimetic materials with specific functions and expanding their applications in biocatalysis.
通过模拟生物分子的中心结构来设计具有高活性和定制生物功能的仿生材料，已成为医学材料发展的重要途径。铁硫（Fe-S）簇作为一种重要的电子载体，具有结构简单、电子传输能力强等优点。为了合理设计和精确构建功能材料，阐明 Fe-S 簇的电子结构和构象关系至关重要。然而，由于其复杂的催化机制和合成过程，很难准确揭示 Fe-S 簇的结构-活性关系。本综述首先介绍了 Fe-S 簇的主要结构类型及其催化机制。然后，系统地介绍了几种典型的仿生 Fe-S 簇的结构设计策略。此外，列举了 Fe-S 簇在生物催化领域的发展，包括肿瘤治疗、抗菌、病毒抑制和植物光保护。最后，总结了 Fe-S 簇存在的问题和发展方向。本综述旨在指导人们在原子水平上准确理解和调控 Fe-S 的电子结构，这对于设计具有特定功能的仿生材料和拓展其在生物催化中的应用具有重要意义。
