Wang Han, Hsu Jessica C, Song Wenyu, Lan Xiaoli, Cai Weibo, Ni Dalong
Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA.
Natl Sci Rev. 2024 Aug 10;11(9):nwae280. doi: 10.1093/nsr/nwae280. eCollection 2024 Sep.
Organ injuries, such as acute kidney injury, ischemic stroke, and spinal cord injury, often result in complications that can be life-threatening or even fatal. Recently, many nanomaterials have emerged as promising agents for repairing various organ injuries. In this review, we present the important developments in the field of nanomaterial-based repair medicine, herein referred to as 'nanorepair medicine'. We first introduce the disease characteristics associated with different types of organ injuries and highlight key examples of relevant nanorepair medicine. We then provide a summary of existing strategies in nanorepair medicine, including organ-targeting methodologies and potential countermeasures against exogenous and endogenous pathologic risk factors. Finally, we offer our perspectives on current challenges and future expectations for the advancement of nanomedicine designed for organ injury repair.
器官损伤，如急性肾损伤、缺血性中风和脊髓损伤，常常会导致危及生命甚至致命的并发症。近年来，许多纳米材料已成为修复各种器官损伤的有前景的药物。在这篇综述中，我们介绍了基于纳米材料的修复医学领域的重要进展，在此称为“纳米修复医学”。我们首先介绍与不同类型器官损伤相关的疾病特征，并重点介绍相关纳米修复医学的关键实例。然后，我们总结了纳米修复医学中的现有策略，包括器官靶向方法以及针对外源性和内源性病理风险因素的潜在应对措施。最后，我们就为器官损伤修复而设计的纳米医学的当前挑战和未来期望发表我们的看法。
