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一种新型锌（II）配合物的合成、动力学、机理及生物活性评估

Synthesis, kinetics, mechanisms, and bioactivity evaluations of a novel Zn(ii) complex.

作者信息

Dey Anwesha, Kumar Ramesh, Dutta Bhramar, Bandopadhyay Rajib, Chakrabortty Sankha, Khan Moonis Ali, Saratale Rijuta Ganesh, Saratale Ganesh Dattatraya, Jeon Byong Hun, Ghosh Alak K

机构信息

Department of Chemistry, The University of Burdwan Burdwan (E) 713104 West Bengal India

Department of Earth Resources & Environmental, Engineering, Hanyang University 222-Wangsimni-ro, Seongdong-gu Seoul 04763 Republic of Korea

出版信息

RSC Adv. 2024 Sep 10;14(39):28693-28702. doi: 10.1039/d4ra03356f. eCollection 2024 Sep 4.

DOI:10.1039/d4ra03356f
PMID:39257653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11384325/
Abstract

Zn(ii)-based anticancer drugs can be suitable alternatives to conventional Pt(ii)-based drugs because of the unique chemical properties of Zn(ii) and low toxicity. In this study, a new hexadentate and heteroleptic Zn(ii) complex ([Zn(bpy)(OAc)], 1) was prepared with a conventional ,-donor ligand (2,2'-bipyridine) and a leaving group (OAc) and characterized ESI-MS, UV-Vis, and FT-IR spectroscopy. Kinetic and mechanistic investigations of 1 were performed using two biologically relevant ligands (dl-penicillamine and l-cysteine) to understand its selectivity and reactivity. Substitution reactions were determined to be two-step processes in the associative activation mode. Bioactivity studies of 1 revealed moderate to strong DNA-binding, cleaving ability, and antimicrobial properties.

摘要

基于锌（II）的抗癌药物由于锌（II）独特的化学性质和低毒性，可能是传统基于铂（II）药物的合适替代品。在本研究中，用传统的给体配体（2,2'-联吡啶）和离去基团（乙酸根）制备了一种新的六齿杂配锌（II）配合物（[Zn(bpy)(OAc)]，1），并通过电喷雾电离质谱（ESI-MS）、紫外可见光谱（UV-Vis）和傅里叶变换红外光谱（FT-IR）进行了表征。使用两种具有生物学相关性的配体（dl-青霉胺和l-半胱氨酸）对1进行了动力学和机理研究，以了解其选择性和反应活性。取代反应被确定为缔合活化模式下的两步过程。1的生物活性研究表明其具有中度至强的DNA结合、切割能力和抗菌性能。

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