Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, Hangzhou, China.
Front Endocrinol (Lausanne). 2024 Aug 26;15:1351982. doi: 10.3389/fendo.2024.1351982. eCollection 2024.
In recent years, the incidence of Endometrial cancer (EC) has been on the rise due to high-fat, high-calorie diets and low-exercise lifestyles. However, the relationships between metabolic disorders and the progression of EC remain uncertain. The purpose of our study was to explore the potential association between obesity, hypertension, hyperglycemia and clinicopathologic characteristics in EC patients.
In categorical variables, Chi-square tests were used to calculate values. Univariate logistic regression and multivariate logistic regression were used to identify the risk factors of myometrial invasion>1/2 and lymph node metastasis. Overall survival (OS) was estimated using the Kaplan-Meier method.
The study included 406 individuals with EC, 62.6% had type I and 37.4% had type II. Hypertension was seen in 132 (32.5%), hyperglycemia in 75 (18.5%), and overweight or obesity in 217 (53.4%). Hypertension, hyperglycemia, and obesity are strongly associated with the clinicopathologic features of EC. Multivariate logistic regression revealed that hyperglycemia (OR=2.439,95% CI: 1.025-5.804, 0.044) was a risk factor for myometrial invasion depth >1/2 in patients with type I EC, and hypertension (OR=32.124,95% CI: 3.287-313.992, 0.003) was a risk factor for lymph node metastasis in patients with type I EC. Survival analysis found that hyperglycemia ( < 0.001) and hypertension ( = 0.002) were associated with OS in type I EC. Neither hyperglycemia, hypertension, nor obesity were associated with the prognosis in type II EC.
Hyperglycemia was a risk factor for myometrial invasion depth >1/2 in patients with type I EC and hypertension was a risk factor for lymph node metastasis in patients with type I EC. Hypertension and hyperglycemia were associated with poor prognosis in patients with type I EC.
近年来，由于高脂肪、高热量的饮食和低运动的生活方式，子宫内膜癌（EC）的发病率呈上升趋势。然而，代谢紊乱与 EC 进展之间的关系尚不确定。我们的研究目的是探讨肥胖、高血压、高血糖与 EC 患者临床病理特征之间的潜在关联。
在分类变量中，采用卡方检验计算 值。采用单因素 logistic 回归和多因素 logistic 回归分析肌层浸润>1/2 和淋巴结转移的危险因素。采用 Kaplan-Meier 法估计总生存期（OS）。
本研究共纳入 406 例 EC 患者，Ⅰ型 62.6%，Ⅱ型 37.4%。高血压 132 例（32.5%），高血糖 75 例（18.5%），超重或肥胖 217 例（53.4%）。高血压、高血糖和肥胖与 EC 的临床病理特征密切相关。多因素 logistic 回归显示，Ⅰ型 EC 患者中，高血糖（OR=2.439，95%CI：1.025-5.804， 0.044）是肌层浸润深度>1/2 的危险因素，高血压（OR=32.124，95%CI：3.287-313.992， 0.003）是Ⅰ型 EC 患者淋巴结转移的危险因素。生存分析发现，高血糖（ < 0.001）和高血压（ = 0.002）与Ⅰ型 EC 的 OS 相关。高血糖、高血压和肥胖均与Ⅱ型 EC 的预后无关。
高血糖是Ⅰ型 EC 患者肌层浸润深度>1/2 的危险因素，高血压是Ⅰ型 EC 患者淋巴结转移的危险因素。高血压和高血糖与Ⅰ型 EC 患者的不良预后相关。
